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We used microarrays to detail Arabidopsis gene expression in response to paraquat, a herbicide that acts as a terminal oxidant of photosystem I that in the light leads to the enhanced generation of superoxide and hydrogen peroxide inside plastids. Within a few hours after paraquat treatment changes ...
ORGANISM(S): Arabidopsis thaliana 
Microtubule nucleation by γ-tubulin ring complexes (γ-TuRCs) must be spatiotemporally controlled to avoid major cell division errors. γ-TuRCs are activated by the centrosome-specific binding of a highly conserved Centrosomin Motif 1 (CM1) domain, but how binding is prevented in the cytosol remains u...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-10-01 | PXD077066 | Pride
The loss of fetal membrane (FM) integrity and function in early pregnancy can have devastating consequences for the fetus and the newborn. However, the current fragmentary knowledge of FM biology has largely hampered the development of preventive FM sealing and healing strategies. Here, by an optimi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD019410 | Pride
Starting from the structure of the human ASF1-histone complex, we developed a rational design strategy combining epitope tethering and optimization of interface contacts to identify a potent peptide inhibitor with a dissociation constant of 3 nM. LC-MS/MS was used to identify in vivo targets of the ...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD013279 | Pride
We used the flu mutant of Arabidopsis to detail gene expression in response to singlet oxygen. The conditional flu mutant of Arabidopsis accumulates excess protochlorophyllide in the dark within chloroplast membranes that upon illumination acts as a photosensitizer and generates singlet oxygen. Imme...
ORGANISM(S): Arabidopsis thaliana 
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