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TranscriptomicsInterference of hemozoin formation in Schistosoma mansoni by quinine reduces experimental schistosomiasis
Background: The parasitic trematode Schistosoma mansoni is one of the major causative agents of human schistosomiasis, which afflicts 200 million people worldwide. Praziquantel is still the only drug used for schistosomiasis treatment and reduction in drug efficiency has prompting the search for ne...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-14751 | biostudies-arrayexpress
UnknownSpecific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines-an exploratory sub-study of the BRACE trial.
Not available
S-EPMC11058726 | biostudies-literature
UnknownMolecular epidemiology and risk factors for nasal carriage of staphylococcus aureus and methicillin-resistant S. aureus in infants attending day care centers in Brazil.
Not available
S-EPMC2786686 | biostudies-literature
ProteomicsComparative proteomic analysis of Plasmodium falciparum parasites with and without the prenol kinase-encoding gene (knockout parasites)
The methylerythritol 4-phosphate (MEP) pathway, essential for producing isoprenoids in Plasmodium parasites. The key isoprenoids produced by the MEP pathway are farnesyl and geranylgeranyl pyrophosphates (FPP and GGPP), vital for protein isoprenylation, ubiquinone, and dolichol biosynthesis. In vitr...
ORGANISM(S): Plasmodium falciparum NF54 
2026-09-16 | PXD059094 | Pride
Geranylgeraniol Knockout Malaria Isoprenoid metabolism Farnesol Plasmodium falciparum Prenol kinase 
UnknownClonal Lineages, Antimicrobial Resistance, and PVL Carriage of Staphylococcus aureus Associated to Skin and Soft-Tissue Infections from Ambulatory Patients in Portugal.
Not available
S-EPMC8063795 | biostudies-literature
GenomicsRif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42298 | biostudies-arrayexpress
TranscriptomicsGene expression modulation by paraquat-induced oxidative stress conditions in P. brasiliensis
Paracoccidioides brasiliensis is a thermodimorphic fungus associated with paracoccidioidomycosis (PCM), the most common systemic mycosis in Latin America. The infection is initiated by inhalation of environmental dispersed conidia produced by the saprophytic phase of the fungus. In the lungs, P. bra...
ORGANISM(S): Paracoccidioides brasiliensis 
2013-06-14 | E-GEOD-41148 | biostudies-arrayexpress
TranscriptomicsTrancriptome analysis of peripheral leukocytes from SARS-CoV-2 infected patients and healthy uninfected individuals during the first wave of COVID-19 pandemic in Brazil
To evaluate the gene expression profiling of peripheral leukocytes in different outcomes of SARS-CoV-2 infections, whole blood samples were collected from individuals with positive SARS-CoV-2 nasopharyngeal swab by RT-PCR (54 patients) and healthy uninfected individuals (12 volunteers). Infected pat...
ORGANISM(S): Homo sapiens 
2022-04-29 | E-MTAB-11240 | biostudies-arrayexpress
UnknownBiological therapy in systemic lupus erythematosus, antiphospholipid syndrome, and Sjogren's syndrome: evidence- and practice-based guidance.
Not available
S-EPMC10150407 | biostudies-literature
UnknownPhenotypic and Molecular Traits of Staphylococcus coagulans Associated with Canine Skin Infections in Portugal.
Not available
S-EPMC8147484 | biostudies-literature
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