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ProteomicsProfiling of Native and Protease_Generated Protein Amino Termini from Formalin-Fixed, Paraffin-Embedded Tissues
Dysregulated proteolysis represents a hallmark of numerous diseases. In recent years, increasing number of studies has begun looking at the protein termini in hope to unveil the physiological and pathological functions of proteases in clinical research. However, the availability of cryopreserved tis...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-25 | PXD002847 | Pride
Ffpe Protease Degradome Tails Proteolysis N-terminomics 
TranscriptomicsTranscriptional profiling of laser-captured spinal motor neurons in the AR100 mouse model of spinal and bulbar muscular atrophy across disease stages
Laser-captured motor neurons (LCM-MN) from spinal cord sections of AR100 SBMA mice and AR20 wild-type controls were isolated at presymptomatic (3 months), symptomatic (12 months), and late-stage (18 months) time points. RNA-seq profiling was performed using Illumina HiSeq paired-end sequencing to in...
ORGANISM(S): Mus musculus 
2026-08-01 | E-MTAB-15768 | biostudies-arrayexpress
UnknownCycloadditions of Donor-Acceptor Cyclopropanes and -butanes using S=N-Containing Reagents: Access to Cyclic Sulfinamides, Sulfonamides, and Sulfinamidines.
Not available
S-EPMC9298015 | biostudies-literature
ProteomicsProteome profiles of primary pancreatic ductal adenocarcinomas undergoing adjuvant chemoradiation link ALDH1A1 to early local recurrence and chemoradiation resistance
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis with very frequent post-surgical local recurrence. The combination of adjuvant chemotherapy with radiotherapy is under consideration to achieve a prolonged disease-free survival (DFS). To date, few studies have determined protein profiles ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-11 | PXD009254 | Pride
Maoa Chemoradiation Aldh1a1 
MetabolomicsEffects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone-treated rats using GC-MS
The standardized extract of Centella asiatica (ECa233) contains >80% triterpenoids with a ratio of madecassoside to asiaticoside of 1.5(±0.5):1. Hepatoprotective effect of ECa233 has not yet been reported. The aim of this study was to examine the effect of ECa233 on liver metabolome of rotenone-trea...
2018-10-11 | MTBLS522 | MetaboLights
UnknownMolecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Not available
S-EPMC6369924 | biostudies-literature
UnknownThe Relationship of Novel Plasma Proteins in the Early Neonatal Period With Retinopathy of Prematurity.
Not available
S-EPMC5053115 | biostudies-literature
ProteomicsProteomics study of skin tissues from RDEB cSCC, low-risk cSCC and metastasizing cSCC
Cutaneous squamous cell carcinoma (cSCC) is the leading cause of death in recessive dystrophic epidermolysis bullosa (RDEB) patients but remains poorly studied on a proteomic level. We aim to characterize the RDEB-SCC proteome by comparing it to the proteomes of UV-light induced cSCC of non-aggressi...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD006914 | Pride
Recessive dystrophic epidermolysis bullosa  cutaneus squamous cell carcinoma  formalin-fixed paraffin-embedded tissue label-free quantitation  liquid chromatography – tandem mass spectrometry 
UnknownLight-driven formation of manganese oxide by today's photosystem II supports evolutionarily ancient manganese-oxidizing photosynthesis.
Not available
S-EPMC7705724 | biostudies-literature
UnknownIdentification of skewed X chromosome inactivation using exome and transcriptome sequencing in patients with suspected rare genetic disease
Not available
S-EPMC11020449 | biostudies-literature
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