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TranscriptomicsTranscription profiling of various types of murine cerebellum cells to investigate the pre-neoplastic stage of medulloblastoma
SUMMARY; Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here we identify a pre-neoplastic stage of medulloblas...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2426 | biostudies-arrayexpress
TranscriptomicsControl of chromatin structure by Spt6 has different consequences in coding and regulatory regions
Spt6 is a highly conserved factor that carries out important functions in transcription and chromatin structure. To gain new insights into Spt6, we measured nucleosome occupancy along Saccharomyces cerevisiae chromosome III in an spt6 mutant and found that the level of nucleosomes is greatly reduced...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-01 | E-GEOD-21787 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 breast cancer cell line treated with dioxin and DMSO control
MCF7 cells were treated with DMSO or 100 nM Dioxin for 16 hr. Gene expression changes were quantified by microarray analyses. Experiment Overall Design: HU133A and B arrays were used to quantify differences in RNA after treatment with 100 nM dioxin for 16 h. The experiment was repeated 3 times.
ORGANISM(S): Homo sapiens 
2007-10-31 | E-GEOD-7765 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages in response to infection with Streptococcus pyogenes
The complex response of murine macrophages to infection with Streptococcus pyogenes was investigated at the level of gene expression using a high-density oligomer microarray. More than 400 genes were identified as being differentially regulated. Many of the up-regulated genes encoded molecules were ...
ORGANISM(S): Mus musculus 
2008-04-05 | E-GEOD-7769 | biostudies-arrayexpress
UnknownEvaluation of Sporicidal Disinfectants for the Disinfection of Personal Protective Equipment During Biological Hazards.
Not available
S-EPMC7047094 | biostudies-literature
TranscriptomicsGlobal gene expression analysis of OsmiRNA156 over expression switchgrass lines
Microarray analysis was performed to determine downstream gene expression effects of miR156 overexpression. Three tillers were collected from each plot, resulting in four biological replicates for each of the four transgenic and ‘Alamo’ nontransgenic control lines.
ORGANISM(S): Panicum virgatum 
2017-10-25 | E-MTAB-5948 | biostudies-arrayexpress
ProteomicsProteome wide measurements of protein half-lives in Mycoplasma pneumoniae
We obtained proteome wide measurements of protein half-lives in M. pneumoniae by performing pulse-chase experiments following SILAC methods. We estimated degradation rates of individual proteins by measuring the increase in light protein compared to heavy protein labeling along the growth curve.
ORGANISM(S): Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
2020-11-24 | PXD016386 | Pride
Degradation rates Protein half-life Silac 
UnknownPTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.
Not available
S-EPMC5884485 | biostudies-literature
ProteomicsThe human diabetes-specific visceral adipose tissue proteome: insights into mechanisms of adipose tissue dysfunction in metabolic disease
Introduction: The human adipose tissue proteome associated with type 2 diabetes (DM) is not well described. An understanding of the DM-specific adipose tissue proteome would provide insight into mechanisms underlying the pathogenesis of DM. Methods: We used label-free proteomics analysis to quanti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-27 | MSV000085169 | MassIVE
ProteomicsDeep Coverage Multi-omic Profiling of C2C12 Dexamethasone Skeletal Muscle Atrophy
Skeletal muscle atrophy and weakness are major contributors to morbidity, prolonged recovery, and long-term disability across a wide range of diseases. Atrophy is caused by breakdown of sarcomeric proteins resulting in loss of muscle mass and strength. Molecular mechanism underlying the onset of mus...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-14 | PXD064871 | Pride
Differentiation C2c12 Skeletal muscle atrophy Dexamethasone Tmt-ms 
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