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TranscriptomicsmicroRNA expression and opioid signaling
To study the relationship between microRNAs and μ-opioid receptor (MOR) signaling, we examined microRNA expression after chronic morphine or fentanyl treatment in rat primary hippocampal neurons and in mouse hippocampus. Mouse cerebellum region was also tested as a negative control to eliminate mic...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-14268 | biostudies-arrayexpress
ProteomicsThe effect of opioid system inhibition on the Hmmr and Col1a1/ Col3a1 gene expression in relation to atherosclerotic plaque formation in aorta.
Atherosclerosis is the most common cardiovascular disease, leading to complications such as myocardial infarction and stroke, the main but not the only causes of which are lipid accumulation and inflammation. In this study, we investigated whether opioid receptor blockade impacts factors involved in...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD064451 | Pride
Aorta Opioid system Naloxone 
TranscriptomicsOpioid exacerbates gut dysbiosis in a murine model Citrobacter rodentium infection
Opioids analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit their use. It has been recently demonstrated that morphine treatment results in significant disruption in gut barrie...
ORGANISM(S): Mus musculus 
2020-02-18 | E-MTAB-7503 | biostudies-arrayexpress
Proteomics: The effects of chronic morphine on the endogenous cannabinoid system in the ventral tegmental area
The United States is currently facing a severe opioid epidemic, therefore addressing how opioids induce rewarding behaviors could be key to a solution for this medical and societal crisis. Recently, the endogenous cannabinoid system has emerged as a hot topic in the study of opioid reward but relati...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-04-08 | PXD023096 | Pride
Ventral tegmental area Cannabinoid receptors Endocannabinoids Opioid Reward Endogenous cannabinoid system 
ProteomicsNaloxone induced alterations in liver proteome and cholesterol level in ApoE-/- mice.
The endogenous opioid system plays a pivotal role in numerous physiological processes and is implicated in a range of diseases, including atherosclerosis, a condition contributing to nearly 50% of deaths in Western societies. This study investigates the effects of opioid receptor blockade using nalo...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD063243 | Pride
Opioid receptors  cholesterol  atherosclerotic plaque  liver steatosis 
GenomicsSpectrotemporal profiling of ultrasonic vocalizations during neonatal opioid withdrawal reveals a kappa opioid receptor component in female mice
Spectrotemporal profiling of ultrasonic vocalizations during neonatal opioid withdrawal reveals a kappa opioid receptor component in female mice
PRJNA1130952 | ENA
GenomicsDOGMA-seq of opioid addiction treatment in HIV-1 infected individuals
DOGMA-seq of opioid addiction treatment in HIV-1 infected individuals
PRJNA981575 | ENA
UnknownAlternatives to Arrest for Illicit Opioid Use: A Joint Criminal Justice and Healthcare Treatment Collaboration.
Not available
S-EPMC7466893 | biostudies-literature
GenomicsMorphine treatment leads to temporal modulation of the gut microbiome
Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit long term use. In the current study using a chronic morphine-murine model a longitudinal approach was undertaken to i...
ORGANISM(S): mouse gut metagenome 
2018-04-16 | E-MTAB-5550 | biostudies-arrayexpress
UnknownOpioid use and opioid use disorder in mono and dual-system users of veteran affairs medical centers.
Not available
S-EPMC10141670 | biostudies-literature
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