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TranscriptomicsSensing Cardiac Electrical Activity with a Cardiomyocyte Targeted Optogenetic Voltage Indicator
Rationale: Monitoring and controlling cardiomyocyte activity with optogenetic tools offers exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage indicators may be particularly attractive for minimal invasive and repeated assessments of cardiac ...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-69190 | biostudies-arrayexpress
TranscriptomicsOptogenetic manipulation of BMP signalling to drive chondrogenic differentiation of hPSCs
Optogenetics is a rapidly advancing technology that combines photochemical, optical and synthetic biology techniques to control cellular behaviour and physiology. Combining sensitive light responsive optogenetic intervention tools with human pluripotent stem cell differentiation models has the poten...
ORGANISM(S): Homo sapiens 
2023-11-09 | E-MTAB-13377 | biostudies-arrayexpress
ProteomicsEngineered allostery in a light-regulated version of TurboID for precise spatiotemporal control of proximity labeling in living cells
Lee SY, Chea JS, Zhao BX, Xu C, Udeshi ND, Roh H, Kim C, Cho K, Carr SA, Ting A. 2022 The incorporation of light-responsive domains into engineered proteins has produced optogenetic tools with the ability to regulate protein localization, interactions, and function with light. We introduced this mod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-09 | MSV000090683 | MassIVE
ProteomicsDirected Differentiation of Human iPSCs into Mesenchymal Lineages by Optogenetic Control of TGF-β Signaling
For chondrogenic studies of optogenetically activated TGF-β signaling, optogenetic human iPSC-derived MSCs were encapsulated in hydrogels (20 million cells/mL of 2% agarose hydrogel). Groups received either no soluble TGF-β or optogenetic stimulation, or soluble TGF-β3 alone, or optogenetic stimulat...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040232 | Pride
Human Ipsc Chondrogenesis Hydrogel Agarose 
ProteomicsChronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer’s disease-like pathology
Neuronal overexcitability can disrupt synapse formation and strength and elicit synaptic changes which in turn give rise to neuronal hyperactivity, and eventually overall abnormal neural circuit processing. Such network disruption impairs neuronal function and survival, resulting in the onset of neu...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-01 | PXD044437 | Pride
Neuronal hyperactivity  hippocampus  optogenetics  stable step function opsin (ssfo)  proteomics  alzheimer’s disease  neurodegeneration 
GenomicsOptogenetic neural stem cells microarray
Optogenetic neural stem cells microarray
PRJNA417074 | ENA
GenomicsSpatiotemporal Control of InflammatoryLytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization
Spatiotemporal Control of InflammatoryLytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization
PRJNA1118192 | ENA
UnknownOptogenetic control of Corynebacterium glutamicum gene expression.
Not available
S-EPMC11662647 | biostudies-literature
GenomicsDevelopmentally-inspired budding morphogenesis by optogenetic receptor tyrosine kinase signaling
Developmentally-inspired budding morphogenesis by optogenetic receptor tyrosine kinase signaling
PRJNA1447937 | ENA
GenomicsEffects of optogenetic and chemogenetic LC activation on the hippocampal transcriptome
Effects of optogenetic and chemogenetic LC activation on the hippocampal transcriptome
PRJNA903150 | ENA
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