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UnknownIs incident rheumatoid arthritis interstitial lung disease associated with methotrexate treatment? Results from a multivariate analysis in the ERAS and ERAN inception cohorts.
Not available
S-EPMC6501950 | biostudies-literature
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsTime course of oxidative stress responses in yeast, caused by Menadione or hydrogen peroxide
Oxidative stress caused by Menadione or Hydrogen peroxide in synchronized Saccharomyces cerevisiae cultures. Alpha factor synchronized cultures (0.2-0.4 OD), treated at the beginning of S phase (25 min after release from G1 arrest) with either 2 mM Menadione (MD) or 0.24 mM Hydrogen peroxide (HP), s...
ORGANISM(S): Saccharomyces cerevisiae 
2005-02-04 | E-GEOD-2239 | biostudies-arrayexpress
UnknownExternal radiation dose reconstruction for settlements near the Semipalatinsk nuclear test site, Kazakhstan, in the international multicenter study: a detailed review and comparative analysis of the initial data.
Not available
S-EPMC12460053 | biostudies-literature
TranscriptomicsHP1 is involved in regulating the global impact of DNA methylation on alternative splicing
The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we found that DNA methylation can act both as an enhancer and as a silencer of splicing, and affects the splicing of more than 20...
ORGANISM(S): Mus musculus 
2015-03-08 | E-GEOD-64910 | biostudies-arrayexpress
ProteomicsBLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures
We ran native 5% polyacrylamide-TBE gel for electro mobility shift assay (EMSA) for DNA/RNA G4 structures with or without recombinant human core-BLM (cBLM) protein, which was extracted and purified from E.coli in order to show binding of the RNA/DNA by this protein. To further evidence, we cut the e...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042983 | Pride
Blm Sg Emsa G-quadruplex Lc-ms/ms 
TranscriptomicsIncreased metastasis with loss of E2F2 in Myc-driven tumors
In human breast cancer, mortality is associated with metastasis to distant sites. Therefore, it is critical to elucidate the biological mechanisms that underlie tumor progression and metastasis. Using signaling pathway signatures we previously predicted a role for E2F transcription factors in Myc i...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-71815 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in the newborn mouse cochlea and vestibule
MicroRNAs (miRNAs) inhibit the translation of target mRNAs and affect, directly or indirectly, the expression of a large portion of the protein-coding genes. This study focuses on miRNAs that are expressed in the mouse cochlea and vestibule, the two inner ear compartments. To identify miRNAs that ar...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-15496 | biostudies-arrayexpress
TranscriptomicsGenome-wide Measurement of RNA Secondary Structure in Yeast
The structures of RNA molecules are often important for their function and regulation, yet there are no experimental techniques for genome-scale measurement of RNA structure. Here, we describe a novel strategy termed Parallel Analysis of RNA Structure (PARS), which is based on deep sequencing fragme...
ORGANISM(S): Saccharomyces cerevisiae 
2010-08-24 | E-GEOD-22393 | biostudies-arrayexpress
TranscriptomicsHP1? has distinct subnuclear localizations, chromatin binding features and functions in embryonic stem cells and differentiating cells [expression]
We used microarrays to identify the gene expression changes in Cbx1-/- (HP1beta) knockout embryonic stem cells (ESCs) and Cbx5-/- (HP1alpha) knockout ESCs compared to WT ESCs and in embryoid bodies (EBs) differentiated from those three ESC types. ESCs were grown and the pluripotent SSEA1-positive ce...
ORGANISM(S): Mus musculus 
2015-08-02 | E-GEOD-65121 | biostudies-arrayexpress
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