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ProteomicsTargeting the UFL1-AKT Cascade Suppresses Triple-Negative Breast Cancer Progression
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease with limited therapeutic options. While UFL1-mediated UFMylation has been implicated in various diseases, its role in TNBC remains unexplored. In this study, we demonstrate that AKT1 directly interacts with UFL1 and unde...
ORGANISM(S): Homo sapiens (Human) 
2025-11-12 | PXD062168 | Pride
Ufl1 Triple-negative breast cancer Akt 
ProteomicsImmunopeptidomic profiling of HLA-A2-positive triple negative breast cancer
Here we analysed the immunopeptidomes of 6 HLA-A2-positive triple negative breast cancer (TNBC) samples by nano-ultra performance liquid chromatography tandem mass spectrometry (nUPLC-MS2).
ORGANISM(S): Homo sapiens (Human) 
2018-06-29 | PXD009738 | Pride
Hla-a2 Immunopeptidomics Tnbc 
ProteomicsA Triple Knockout (TKO) Proteomics Standard for Diagnosing Ion Interference in Isobaric Labeling Experiments
Isobaric labeling is a powerful strategy for quantitative mass spectrometry-based proteomic investigations. A complication of such analyses has been the co-isolation of multiple analytes of similar mass-to-charge resulting in the distortion of relative protein abundance measurements across samples. ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-10-26 | PXD008009 | Pride
Ion interference Ms standard Tmt Muiltinotch Lumos Orbitrap fusion 
ProteomicsA Triple Knockout (TKO) Proteomics Standard for Diagnosing Ion Interference in Isobaric Labeling Experiments
Isobaric labeling is a powerful strategy for quantitative mass spectrometry-based proteomic investigations. A complication of such analyses has been the co-isolation of multiple analytes of similar mass-to-charge resulting in the distortion of relative protein abundance measurements across samples. ...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2019-08-23 | MSV000084230 | MassIVE
Proteomicsproteome profiling using Orbitrap Fusion
Fresh frozen tumor tissues with less than 30% non-tumor tissue were macrodissected for further use. The percentage of tumor purity was confirmed to be 50% or more in all tumor specimens. Collected specimens were stored in a -80℃ refrigerator until being used for proteomics analysis. 15 Proteomic Ana...
2023-07-26 | OEX00014789 | NODE
ProteomicsComprehensive proteomic characterization reveals subclass-specific molecular aberrations within triple-negative breast cancer
Triple-negative breast cancer (TNBC) is regarded as the most aggressive subtype of breast cancer lacking targeted therapies. This is attributed to its high heterogeneity that complicates elucidation of its molecular aberrations. Here, we report identification of specific proteome expression profiles...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD017025 | Pride
Triple-negative Tnbc Proteomics Mass spectrometry Protease Breast cancer Kinase 
ProteomicsECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and the lack of specific signature makes difficult the development of targeted therapeutic strategy. We previously found that PRICKLE1, an evolutionary conserved protein acting as a regulator of vertebrate development,...
ORGANISM(S): Homo sapiens (Human) 
2019-10-15 | PXD011253 | Pride
Lc-msms Therapeutic targets Triple negative breast cancer Signaling Interactome Prickle1 Ect2 
ProteomicsMulti-omics analysis of triple-negative breast cancers
Abstract The triple-negative breast cancer (TNBC) accounts for approximately 15% of all Breast Cancer (BC) cases. However, the prognosis and clinical outcomes of TNBC are worse than those of other BC subtypes due to a greater tumor and few therapeutically targetable oncogenic drivers. Numerous studi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-28 | MSV000095715 | MassIVE
ProteomicsQuantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors
Metaplastic breast carcinoma (MBC) is the most aggressive form of triple-negative cancer (TNBC), defined by the presence of “metaplastic” components of spindle, squamous, or sarcomatoid histology. The protein profiles underpinning the pathological subtypes and metastatic behavior of MBC are unknown....
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-04-22 | PXD014414 | Pride
Tandem mass tag (tmt) labeling Precision therapy Wisp3 Metaplastic breast carcinoma Lc-ms/ms shotgun proteomics Ccn6 Triple-negative breast cancer 
ProteomicsMulti-omics data integration reveals correlated regulatory features of triple negative breast cancer
Triple negative breast cancer is an aggressive type of breast cancer with very little treatment options. TNBC is very heterogeneous with large alterations in the genomic, transcriptomic, and proteomic landscapes leading to various subtypes with differing responses to therapeutic treatments. We appli...
ORGANISM(S): Homo sapiens (Human) 
2021-06-24 | PXD025238 | Pride
Multi-omics data integration Phosphoproteomics Triple negative breast cancer Histone posttranslational modification Rna-seq 
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