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TranscriptomicsOrientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons. In mice, six additional sets of c...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-71005 | biostudies-arrayexpress
TranscriptomicsPcs1 and Mde4 are inner centromere proteins required to prevent merotelic kinetochore orientation
Chromosome segregation depends on proper attachment of sister kinetochores to microtubules. Merotelic kinetochore orientation is an error which occurs when a single kinetochore is attached to microtubules emanating form opposite poles. Mechanisms preventing or correcting the merotelic attachment mus...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-10 | E-GEOD-5257 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling for Plk2 -/- mammary gland
Identify gene expression changes in the absence of Plk2 Disruptions in polarity and mitotic spindle orientation contribute to the progression and evolution of tumorigenesis. However, little is known about the molecular mechanisms regulating these processes in vivo. Here we demonstrate that Polo-like...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50003 | biostudies-arrayexpress
ProteomicsCentrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
The orientation of the mitotic spindle (MS) is tightly regulated, but the molecular mechanisms are incompletely understood. Here we report a novel role for the multifunctional adaptor protein ALG-2-interacting protein X (ALIX) in regulating MS orientation in addition to its well-established role in ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-04 | PXD009747 | Pride
Mitotic spindle orientation Alix Microtubule G-tubulin Map1s 
ProteomicsNew method to investigate protein orientation in corona of nanomaterials
The composition and structure of protein corona represents a crucial factor that controls the biological properties and fate of nanomaterials. While the composition of the corona can relatively easily be investigated by conventional bottom-up proteomics, assessing the spatial orientation of a protei...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019524 | Pride
Isobaric labeling Orientation Protein corona 
GenomicsThe budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo
High resolution ChIP-seq mapping, supported by in vitro reconstitution studies, suggests that the Cse4 nucleosome is a hemisome that occupies the ~80-bp AT-rich CDEII sequence. H4S47C-anchored cleavage mapping of S. cerevisiae centromeres
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-15 | E-GEOD-51949 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of tobacco (Nicotiana tabacum) plants in response to sulfur deficiency
The experiment was aimed at identification of genes whose expression is up- or down-regulated in tobacco plants in response to sulfur (S) deficiency. Comparison of response to S deficit of LA Burley 21 line and AB3 line (overexpressing UP9C in antisense orientation) was done to clarify the function ...
ORGANISM(S): Nicotiana tabacum 
2013-02-14 | E-MEXP-3699 | biostudies-arrayexpress
GenomicsChromatin-intrinsic mechanisms determine orientation-specific class switch recombination [ChIP-Seq]
Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination [ChIP-Seq]
PRJNA1274249 | ENA
GenomicsChromatin-intrinsic mechanisms determine orientation-specific class switch recombination [3C-HTGTS]
Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination [3C-HTGTS]
PRJNA1274854 | ENA
GenomicsChromatin-intrinsic mechanisms determine orientation-specific class switch recombination [PRO-seq]
Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination [PRO-seq]
PRJNA1277783 | ENA
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