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ProteomicsMETABOLIC DISRUPTION IMPAIRS RIBOSOMAL PROTEIN LEVELS, RESULTING IN ENHANCED AMINOGLYCOSIDE TOLERANCE
Aminoglycoside antibiotics display broad-spectrum activity against Gram-negative and Gram-positive bacteria by targeting their ribosomes. Herein, we have demonstrated that energy metabolism plays a crucial role in aminoglycoside tolerance, as knockout strains associated with the tricarboxylic acid c...
ORGANISM(S): Escherichia coli 
2024-06-21 | PXD053082 | Pride
Ribosomal proteins Lc-ms Tca cycle E. coli 
ProteomicsGlycerol-Driven Energy and Proteostasis Underpin Antibiotic Tolerance in Escherichia coli
Bacterial persisters are frequently described as metabolically dormant, yet the endogenous metabolic programs that sustain survival during prolonged nutrient limitation remain poorly understood. Here, using stationary-phase Escherichia coli as a model of antibiotic tolerance, we combine proteomics, ...
ORGANISM(S): Escherichia coli 
2026-06-12 | PXD079272 | Pride
Persister  escherichia coli  metabolism  tca cycle  protein aggregation  large polar aggregates  phospholipid recycling 
ProteomicsThe Role of c-Jun Signaling in Cytidine Analog-Induced Cell Death in Melanoma
Melanoma stands as an increasingly pressing health concern. Enhanced mitochondrial metabolism has been reported in melanoma cells that survived treatment with traditional therapeutics, including cytidine analogs like gemcitabine (GEM). These findings suggest that chemotherapeutic drugs may play dual...
ORGANISM(S): Homo sapiens (Human) 
2026-10-07 | PXD060382 | Pride
Jnk C-jun Melanoma Apoptosis Chemotherapy Cancer 
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