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ProteomicsDIA Proteomic Profiling of Mouse Lung Tissues Reveals the Antifibrotic Effects of Osmundacetone in Bleomycin-Induced Pulmonary Fibrosis
This study investigated the antifibrotic effects of osmundacetone (OSMA) in a bleomycin-induced mouse model of pulmonary fibrosis. Data-independent acquisition (DIA)-based quantitative proteomics was performed to characterize protein expression changes in mouse lung tissues from control, pulmonary f...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-19 | PXD085814 | Pride
Bleomycin Pulmonary fibrosis Extracellular matrix Orbitrap astral Mouse lung tissue Osmundacetone Dia proteomics Lc-ms/ms 
TranscriptomicsTranscriptomic profiling of mouse lung tissue after osmundacetone treatment in bleomycin-induced pulmonary fibrosis
To investigate the transcriptional response to osmundacetone (OSMA) in pulmonary fibrosis, lung tissue RNA was sequenced from male C57BL/6J mice in control, bleomycin model, and bleomycin plus high-dose OSMA groups. Four samples were analyzed per group. The study examined disease-associated expressi...
ORGANISM(S): Mus musculus 
2026-10-22 | GSE351289 | GEO
TranscriptomicsTranscriptomic profiling of TGF-beta1-induced A549 cells treated with osmundacetone
Pulmonary fibrosis is characterized by excessive extracellular matrix deposition and progressive loss of lung function. This study evaluated the transcriptional response of A549 alveolar epithelial cells to the natural compound osmundacetone (OSMA) in a TGF-beta1-induced profibrotic model. RNA seque...
ORGANISM(S): Homo sapiens 
2026-10-22 | GSE351288 | GEO
UnknownDisarming the Pathogenicity of Methicillin-Resistant Staphylococcus aureus via Osmundacetone-Mediated Inhibition of Sortase A.
Not available
S-EPMC12070378 | biostudies-literature
UnknownPhellinus baumii Polyphenol: A Potential Therapeutic Candidate against Lung Cancer Cells.
Not available
S-EPMC9782521 | biostudies-literature
UnknownTriterpenes and Phenolic Compounds from the Fungus Fuscoporia torulosa: Isolation, Structure Determination and Biological Activity.
Not available
S-EPMC8002351 | biostudies-literature
MetabolomicsPolyphenolic Profiling of Plants and Edible Mushrooms to Aid Characterizing Polyphenol Oxidase Selectivity

Polyphenol oxidases are important metalloenzymes that catalyze the oxidation of polyphenols. Organisms can contain multiple isoenzymes whose possible different functionality is not understood. Moreover, their substrate preference is still unexplored, and a working hypothesis assumes their specifi...

2025-08-07 | MTBLS8782 | MetaboLights
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