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MetabolomicsThe Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

Summary

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS...

2022-02-18 | MTBLS4013 | MetaboLights
ProteomicsA Simple Method to Isolate and Characterize a Bacterial Outer Membrane Proteome by Bottom-Up Mass Spectrometry
The outer membrane of gram-negative bacteria plays a critical role in protecting the cell against external stressors, including antibiotics. Given its importance to the resistance mechanisms, the outer membrane is a prime target for antimicrobial drug discovery. To facilitate discovery efforts, howe...
ORGANISM(S): Escherichia coli 
2023-03-11 | PXD036749 | Pride
Peptidiscs Outer membrane proteome Antibiotic resistance E. coli 
ProteomicsLocalisation of outer membrane proteins in Treponema denticola by quantitative proteome analyses of outer membrane vesicles and cellular fractions
The identification and localisation of outer membrane proteins (Omps) and lipoproteins in pathogenic treponemes such as T. denticola (periodontitis) and T. pallidum (syphilis) has been challenging largely due to the structural uniqueness of their outer membranes (OM), the high abundance of inner mem...
ORGANISM(S): Treponema denticola ATCC 35405 
2019-02-20 | PXD011495 | Pride
Treponema denticola Localization Outer membrane vesicles Bacterial lipoproteins Maxquant Outer membrane proteins Orbitrap 
ProteomicsCross-species proteomic comparison of whole cell lysates, outer membrane vesicles and membrane fractions of Francisella tularensis subsp. tularensis versus subsp. holarctica
Secretion of outer membrane vesicles (OMV) presents an important phenomenon in Gram-negative bacteria and they play multiple roles in their lifestyle including virulence and host-pathogen interaction. Francisella tularensis secretes unusually shaped tubular OMV. We here present a proteomic compariso...
ORGANISM(S): Francisella tularensis Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. holarctica FSC200 
2021-02-08 | PXD022406 | Pride
Q-exactive Schus4 Outer membrane vesicles Fsc200 Cross-species proteomic comparison Francisella tularensis 
ProteomicsTamL is a key player of the outer membrane homeostasis in Bacteroidetes.
In Proteobacteria, the outer membrane protein TamA and the inner membrane-anchored protein TamB form the Translocation and Assembly Module (TAM) complex, which facilitates the transport of autotransporters, virulence factors, and likely lipids across the two membranes. In Bacteroidetes, TamB co-oc...
ORGANISM(S): Flavobacterium johnsoniae 
2025-03-11 | PXD056806 | Pride
Membrane vesicles Tam complex Proteomics Lipidomics Lc-ms Bacteroidetes Outer membrane Lipoproteins 
ProteomicsThe proteome of Fibrobacter succinogenes S85 outer membrane vesicles
Here, we illustrate the proteomic composition and hydrolytic capacity of outer membrane vesicles (OMVs) produced by F. succinogenes during growth on Avicel cellulose and show that the OMVs are equipped with a highly versatile polysaccharide-degrading machinery. Proteomic assessment identified an enr...
ORGANISM(S): Fibrobacter succinogenes subsp. succinogenes S85 
2017-06-30 | PXD005442 | Pride
Outer membrane vesicles Omv Hydrolytic enzymes 
ProteomicsProfiling antibody responses to M. tuberculosis proteins in TB suspects’ sera using full-proteome microarrays.
Understanding the immune response to tuberculosis requires greater knowledge of humoral responses. To characterize antibody targets and the effect of disease parameters on target recognition, we developed a systems immunology approach that integrated detection of antibodies against the entire Mycob...
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-19433 | biostudies-arrayexpress
ProteomicsProteome of mass-produced Escherichia coli outer membrane vesicles
Large-scale production of bacterial extracellular vesicles is a hurdle for their development as novel cancer immunotherapeutic agents. Here, we developed manufacturing processes for mass production of Escherichia coli EVs known as outer membrane vesicles (OMVs). We present a comprehensive proteome o...
ORGANISM(S): Escherichia coli Bacteria 
2023-10-24 | PXD043119 | Pride
Escherichia coli Outer membrane vesicles Mass production Lc-ms/ms 
ProteomicsOuter membrane utilisomes mediate oligosaccharide uptake in gut Bacteroidetes
Bacteroidetes are abundant members of the human microbiota, and species occupying the distal gut are capable of utilising a myriad of diet- and host-derived glycans. Transport of glycans across the outer membrane (OM) of these bacteria is mediated by SusCD protein complexes. Additionally, cell surfa...
ORGANISM(S): Bacteroides thetaiotaomicron Bacteria 
2023-06-19 | PXD034863 | Pride
Outer membrane proteome Microbiota Glycan utilisation Gut bacteroidetes 
ProteomicsOuter Membrane Proteome of Veillonella parvula: a Diderm Firmicute of the Human Microbiome
Veillonella parvula is a biofilm-forming commensal found in the lungs, vagina, mouth, and gastro-intestinal tract of humans, yet it may also develop into an opportunistic pathogen. Furthermore the presence of Veillonella has been associated with the development of a healthy immune system in infants....
ORGANISM(S): Veillonella parvula DSM 2008 
2017-07-19 | PXD005929 | Pride
Outer membrane proteome Veillonella parvula 
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