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ProteomicsMultiple sclerosis cuprizone mouse model and vitamin D supplementation
Dietary supplementation of vitamin D is commonly recommended to patients with multiple sclerosis (MS). We investigated the effect of 1,25-dihydroxyvitamin-D3 (1,25-(OH)2D3) on the brain proteome in the cuprizone model during remyelination. Mice were demyelinated with dietary cuprizone for 7 weeks. T...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-16 | PXD002347 | Pride
Mouse Multiple sclerosis Vitamin d Cuprizone tmt 
ProteomicsPeli1 knock-out and wild type mouse brain proteomes during the disease course of experimental autoimmune encephalomyelitis
The ubiquitin ligase Peli1 has previously been suggested as a potential treatment target in multiple sclerosis since the knock-out induced less activated microglia and less inflammation in the CNS of experimental autoimmune encephalomyelitis in mice. In the present study the brain proteomes of Peli1...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-27 | PXD003710 | Pride
Tmt Label-free Eae Cns Peli1 Multiple sclerosis Quantitative proteomics 
ProteomicsMuscular invasiveness in bladder cancer
Patients with bladder cancer need frequent controls over long follow-up time due to high recurrence rate and risk of conversion to muscle invasive cancer with poor prognosis. We identified cancer-related molecular signatures in apparently healthy bladder in patients with subsequent muscular invasive...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD010260 | Pride
Human Bladder cancer Label-free proteomics Q-exactive-hf 
ProteomicsFingolimod and remyelination - Fingolimod downregulates brain sphingosine-1-phosphate receptor 1 levels but does not promote remyelination or neuroprotection in the cuprizone model
Remyelinating substances could be an essential supplement to immunomodulatory medications, optimizing the treatment of multiple sclerosis (MS) patients. Fingolimod is a sphingosine-1-phosphate receptor (S1PR) modulator and crosses the blood-brain barrier. Central nervous system (CNS) cells express S...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-20 | PXD012676 | Pride
Brain Cpz Tissue Proteomics Tmt Mass spectrometry Qe-hf Fingolimod Mouse Multiplexing 
ProteomicsMultiple sclerosis resaerch: EAE and cuprizone mouse brain TMT and label-free proteomics
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, and in this study we used quantitative proteomics to compare the brain proteomes of two MS mouse models, the immune-mediated experimental autoimmune encephalomyelitis (acute and recovery phase) and...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-16 | PXD002318 | Pride
Orbitrap velos Mus musculus Brain Tmt Label-free 
ProteomicsEPAC1 knockout mouse effects in platelets and plasma
ABSTRACT FOR BOTH PLASMA AND PLATELET-LYSATE In this article we describe the involvement of exchange factor activated by cAMP 1 (Epac1) in hemostasis and platelet activation. We have used plasma and platelet-lysate from EPAC1 knockout mice and wild-type control mice in label-free proteomics with an ...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-25 | PXD000282 | Pride
Epac1 knockout Platelets Lc-ms Plasma Label-free 
OtherIn-depth characterization of the cerebrospinal fluid proteome displayed through the CSF Proteome Resource (CSF-PR).
Data from ProteomeXchange, PXD ID: PXD000656. File: folder summary. Published as part of . From ProteomeXchange: {{i}} 40 uL plasma from a pool of 20 neurologically healthy donors was separated into a bound and a depleted fraction using a MARS Hu-14 column. This experiment represents the bound frac...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320001835 | GPMDB
Resource Reanalysis 
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