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ProteomicsRapid single-step affinity purification of HA-tagged mitochondria from Arabidopsis thaliana
Photosynthesis in plant cells would not be possible without the supportive role of mitochondria. However, isolating mitochondria for physiological and biochemical analyses from plant cells is a lengthy and tedious process. Established isolation protocols require multiple centrifugation steps and sub...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-11-14 | PXD014137 | Pride
Arabidopsis Mitochondria Lc-ms/ms 
ProteomicsMechanism of BceAB-type transporter: Resistance by lipid II flipping
Treatment of bacterial infections are the great challenge of our era due to the evolved resistance mechanisms against antibiotics. The Achilles heel of bacteria is the cell wall especially during the needs of its synthesis and cell division. Here lipid II is an essential precursor component synthesi...
ORGANISM(S): Bacteria Lactococcus lactis subsp. cremoris NZ9000 
2022-04-04 | PXD017318 | Pride
Bceab-type Bacitracin Nisin Antibiotic resistance Lipid ii 
ProteomicsARID1A regulates transcription and the epigenetic landscape via POLE and DMAP1 while ARID1A deficiency or pharmacological inhibition sensitizes germ cell tumor cells to ATR inhibition
Germ cell tumors (GCTs) are the most common solid malignancies in young men. Although high cure rates can be achieved at early stages, metastases, resistance to cisplatin-based therapy, and late toxicities still represent a lethal threat, arguing for the need of new therapeutic options. In a previou...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD017898 | Pride
Molecular therapy Swi/snf-complex Mass spectrometry Hdac inhibitors Crispr/cas9 Atr inhibitors Arid1a Germ cell tumors 
ProteomicsHHIP-AS1 lncRNA promotes tumorigenicity in human SHH-driven brain tumors
Long non-coding RNAs (lncRNAs) comprise a diverse class of gene expression regulators with emerging roles in many biological processes including cancer. Here we show that the expression of the lncRNA Hedgehog Interacting Protein Antisense 1 (HHIP-AS1) is a hallmark feature of human SHH-driven tumors...
ORGANISM(S): Homo sapiens (Human) 
2022-06-01 | PXD016550 | Pride
Pediatric brain tumors Lncrna Epigenetic regulation Shh Proteogenomic 
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