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ProteomicsThe ribosomal P-stalk regulates MHC I antigen presentation
MHC I antigen processing and presentation (APP) is a highly regulated process that enables CD8+ T cell immunosurveillance. APP begins with the ribosomal synthesis of a source antigen, yet the role of ribosomes, particularly specialized ribosomes, in antigen presentation is poorly understood. Here, w...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD041688 | Pride
Ribosomal P1 T cell Cd8 Lc-msms P-stalk 
GenomicsP-stalk ribosomes act as master regulators of cytokine-mediated processes
P-stalk ribosomes act as master regulators of cytokine-mediated processes
PRJNA957309 | ENA
OtherP-stalk ribosomes act as master regulators of cytokine-mediated processes
HLA Class I antigen processing and presentation (APP) is a highly regulated process that enables CD8+ T cell immunosurveillance. APP begins with the ribosomal synthesis of a source antigen, yet the role of ribosomes, particularly specialized ribosomes, in antigen presentation is poorly understood. H...
ORGANISM(S): Homo sapiens 
2024-10-23 | GSE230060 | GEO
ProteomicsEukaryotic Ribosome GCN2 interaction Hydrogen/Deuterium Exchange Mass Spectrometry
General control nonderepressible 2 (GCN2) phosphorylates eIF2α, regulating translation in response to nutritional stress. Here, we show that mammalian ribosomes are potent GCN2 activators. Hydrogen/deuterium exchange–mass spectrometry (HDX-MS) showed GCN2 interacting with domain II of the uL10 P-sta...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2019-05-24 | PXD013051 | Pride
Ribosome Gcn2 Hdx-ms 
UnknownActivation of GCN2 by the ribosomal P-stalk.
Not available
S-EPMC6421407 | biostudies-literature
UnknownP-stalk ribosomes act as master regulators of cytokine-mediated processes.
Not available
S-EPMC11896023 | biostudies-literature
UnknownMultiplication of Ribosomal P-Stalk Proteins Contributes to the Fidelity of Translation.
Not available
S-EPMC5559677 | biostudies-literature
UnknownSingle-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
Not available
S-EPMC8941211 | biostudies-literature
UnknownDirect visualization of translational GTPase factor pool formed around the archaeal ribosomal P-stalk by high-speed AFM.
Not available
S-EPMC7768734 | biostudies-literature
UnknownPhosphorylation of P-stalk proteins defines the ribosomal state for interaction with auxiliary protein factors.
Not available
S-EPMC11624264 | biostudies-literature
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