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TranscriptomicsMetabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis
The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms by which stromal cells influence the tumor epithelium are poorly understood. The signaling adapter p62 has been implicated as a positive regulator of epithelial tumorigenesis; however, its role in the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-55587 | biostudies-arrayexpress
TranscriptomicsDepletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice
Huntington's disease (HD) is a dominantly inherited genetic disease caused by mutant huntingtin (htt) protein with expanded polyglutamine tracts. A neuropathological hallmark of HD is the presence of neuronal inclusions of mutant htt. p62 is an important regulatory protein in selective autophagy, ...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-62210 | biostudies-arrayexpress
MetabolomicsTranscript, protein and metabolite temporal dynamics in the CAM plant Agave
Already a proven mechanism for drought sustainability, crassulacean acid metabolism (CAM) is a specialized type of photosynthesis that maximizes water-use efficiency (WUE) via an inverse (compared to C3 and C4 photosynthesis-performing species) day/night pattern of stomatal closure/opening to shift ...
2017-10-13 | MTBLS363 | MetaboLights
MetabolomicsBacteria encode their own post-mortem protein catabolism to enable nutrient recycling
For many organisms, death is a tangible, visible event. In bacteria, death can be a natural or an induced process 1. Death permits genes conferring a survival advantage to be selected in a bacterial population. Furthermore, biomolecule recycling from dead bacteria is crucial under nutrient limitatio...
2025-01-23 | MTBLS10044 | MetaboLights
ProteomicsSpecies-specific cleavage of the autophagy adaptor p62 dictates responses to TNF
Inflammation is a driver of many diseases including cancer. Several studies have also shown that changes to macroautophagy can affect inflammation. We were interested in these connections and we report here that the autophagy adaptor proteins p62/SQSTM1 is cleaved upon treatment with the inflammat...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD065587 | Pride
Autophagy Tnf Inflammation Caspase Protein cleavge Apoptosis P62 
ProteomicsAcetylation of p62 regulates base excision repair through interaction with APE1
p62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report a function for p62 in base excision repair that is distinct from its known functions. Loss of p62 impairs BER capacity and increases the sensitivity of cancer cells to alkylating and oxi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD034901 | Pride
Sirt7 Ape1 P62 Base excision repair Acetylation Hmof 
MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
MetabolomicsThe Impact of Ethnicity and Intra-Pancreatic Fat on the Postprandial Metabolome Response to Whey Protein in Overweight Asian Chinese and European Caucasian Women with Prediabetes
The 'Thin on the Outside Fat on the Inside' TOFI_Asia study found Asian Chinese to be more susceptible to Type 2 Diabetes (T2D) compared to European Caucasians matched for gender and body mass index (BMI). This was influenced by degree of visceral adipose deposition and ectopic fat accumulation in k...
2022-10-12 | MTBLS5568 | MetaboLights
ProteomicsAcetylation of p62 regulates base excision repair through interaction with APE1
p62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report a function for p62 in base excision repair that is distinct from its known functions. Loss of p62 impairs BER capacity and increases the sensitivity of cancer cells to alkylating and oxi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD034899 | Pride
Sirt7 Ape1 P62 Base excision repair Acetylation Hmof 
GenomicsCardiac p62/Sqstm1 maintains Nrf2 protein levels and protects from oxidative stress
Cardiac p62/Sqstm1 maintains Nrf2 protein levels and protects from oxidative stress
PRJNA802961 | ENA
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