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ProteomicsAn extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation
The ErbB4 receptor isoforms JM-a and JM-b differ within their extracellular juxtamembrane (eJM) domains. Here, ErbB4 isoforms are used as a model to address the effect of structural variation in the eJM domain of receptor tyrosine kinases (RTK) on downstream signaling. A specific JM-a-like sequence ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-30 | PXD026546 | Pride
Receptor tyrosine kinase Jm-a Rtk Stat signaling Erbb4 Jm-b 
ProteomicsQuantitative proteomic analysis of HIV-1 Tat-induced dysregulation in SH-SY5Y neuroblastoma cells
Despite affecting up to 70% of HIV+ patients and being the leading cause of dementia in patients under 40 years, the molecular mechanisms involved in the onset of HAND are not well understood. To address this, we performed SILAC-based quantitative proteomic analysis on HIV-Tat treated SH-SY5Y neurob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-18 | MSV000083590 | MassIVE
ProteomicsIdentification of spidroin proteins in the silk glands of Nephila clavipes spiders
Glands were frozen at -80 ºC immediately after being retrieved and stored under this condition until initiating the proteomics analysis protocol. Glands were washed with cold PBS and immersed in 120 l of homogenization buffer (50 mM Tris-HCl, pH 6.8, 10 mM DTT, 4% (w/v) SDS). Glands were boiled for ...
ORGANISM(S): Trichonephila clavipes 
2022-12-07 | PXD023141 | Pride
Spider silk  proteomics  liquid chromatography-tandem mass spectrometry  silk gut 
UnknownVertical Self-Rectifying Memristive Arrays for Page-Wise Parallel Logic and Arithmetic Processing.
Not available
S-EPMC12878806 | biostudies-literature
UnknownEpigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure.
Not available
S-EPMC5226705 | biostudies-literature
ProteomicsProteomic analysis of exported chaperone/co－chaperone complexes of P. falciparum reveals an array of complex protein-protein interactions
Project describe: The P. falciparum export 300-400 proteins during infect human red blood cell, where they are involved in host cell modification including We recently identified a novel structure in P. falciparum-infected erythrocytes which we refer to as J-dots. These structures contain exported p...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2018-10-18 | PXD003789 | Pride
P. falciparum Red blood cell Co-ip J-dots Lc-ms/ms 
UnknownPleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study.
Not available
S-EPMC4366224 | biostudies-literature
ProteomicsCx37 Phosphorylation and cell cycle regulation
Using alanine and aspartate substitutions to mimic dephosphorylated and phosphorylated Cx37, respectively, we showed that induced expression of Cx37 in rat insulinoma cells could arrest cell cycle progression, support cell cycle progression or cause cell death in a phosphosite specific manner. In th...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-13 | PXD012191 | Pride
Gap junction  growth arrest  proliferation  cell death  differential phosphorylation 
UnknownPleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia.
Not available
S-EPMC3982896 | biostudies-literature
ProteomicsEndothelial pathomechanisms in response to in vivo peritoneal dialysis fluid exposure
Loss of ultrafiltration capacity in peritoneal dialysis (PD) patients is often associated with peritoneal vascular changes, manifest as diabetes-like vasculopathy and angiogenesis. The endothelial monolayer lining the vessel lumen controls vessel barrier function and thereby influences peritoneal su...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022183 | Pride
Tmt Dialysis Human arterioles 
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