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TranscriptomicsATAC-seq experiment at four time points in HEK293 and hESC cells, assessing the time-resolved response on chromatin accessibility upon Wnt/β-catenin signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin -driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes huma...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12076 | biostudies-arrayexpress
TranscriptomicsATAC-seq time-course profiling upon Wnt stimulation in ΔCTNNB1 HEK293T cells
Wnt/β-catenin signaling is generally thought to activate transcription primarily through pre-accessible regulatory elements. However, we previously identified cases in which β-catenin associates with initially inaccessible chromatin regions that subsequently gain accessibility (E-MTAB-12076, Pagella...
ORGANISM(S): Homo sapiens 
2026-05-24 | E-MTAB-16975 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment at four time points in HEK293 and hESC cells, assessing the time-resolved response on gene expression upon Wnt/β-catenin signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12075 | biostudies-arrayexpress
ProteomicsNogo-A modulates gene expression to fine-tune enamel development
Nogo-A is a major player in neural development and regeneration, and it is the target of several clinical trials. However, its functions outside the nervous system are mostly unknown. We observed that Nogo-A is expressed in dental epithelial cells, responsible for the formation of enamel, and we sho...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-20 | PXD030386 | Pride
Differentiation Amelogenesis Lc-ms Tooth Interactome Nogo-a Development Enamel Transcriptome Dda 
TranscriptomicsCUT&RUN experiment at four time points in HEK293T and hESC cells, assessing the time-resolved response of β-catenin genomic occupancy upon Wnt signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12077 | biostudies-arrayexpress
TranscriptomicsCUT&RUN LoV-U of beta-catenin, TCF/LEF transcription factors and histone modifications in HEK293T and mouse embryonic hindlimb tissue at 11.5 days post coitum
In our attempts to profile different regulators of the WNT/b-catenin transcriptional complex, CUT&RUN failed to produce consistent binding patterns of the non-DNA-binding b-catenin. We developed a modified CUT&RUN protocol, which we refer to as LoV-U (Low Volume and Urea), that enables the generatio...
ORGANISM(S): Mus musculus 
2022-07-16 | E-MTAB-11951 | biostudies-arrayexpress
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