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TranscriptomicsRegulation of the microRNA processor DGCR8 by the tumor suppressor ING1
The ING familiy of tumor suppressor proteins control several cellular functions relevant to anti-tumor protection, like cell-cycle control, apoptosis, senescence or migration. ING proteins are functionally linked to the p53 pathway, and they participate in transcriptional control via the recognisit...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18645 | biostudies-arrayexpress
ProteomicsCirculating endoglin induces hypertension via the upregulated expression of BMP4
Endoglin is a membrane glycoprotein primarily expressed by the vascular endothelium and involved in cardiovascular diseases. Upon the proteolytic processing of the membrane-bound protein, a circulating form of endoglin (soluble endoglin, sEng) can be released, and high levels of sEng have been obser...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD016228 | Pride
Tgf-β Endothelial cells Preeclampsia Hypertension Endoglin Hht Bmp4 
TranscriptomicsAnalysis of gene expression profiles in primary embryonic fibroblasts deficient for the Ing1 locus
The ING familiy of tumor suppressor proteins control several cellular functions relevant to anti-tumor protection, like cell-cycle control, apoptosis, senescence or migration. ING proteins are functionally linked to the p53 pathway, and they participate in transcriptional control via the recognition...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-18519 | biostudies-arrayexpress
ProteomicsProteomic characterization of transcription and splicing factors associated with a more invasive phenotype in colorectal cancer
To find new transcription and splicing factors associated with the metastatic phenotype we used a concatenated tandem array of consensus transcription factors response elements (catTFRE) on nuclear extracts of colon cancer cell lines. We used two different isogenic pairs of colorectal metastatic cel...
ORGANISM(S): Homo sapiens (Human) 
2017-11-15 | PXD006662 | Pride
Human Lc-msms Transcription Colon cancer Splicing Cell lines Metastasis 
TranscriptomicsING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth
ING proteins play an essential role in the control of a variety of cellular functions whose deregulation is associated with tumor formation and dissemination, such as proliferation, apoptosis, senescence or invasion. Accordingly, loss of function of ING proteins is a frequent event in many types of...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-42412 | biostudies-arrayexpress
UnknownClinPrior: an algorithm for diagnosis and novel gene discovery by network-based prioritization.
Not available
S-EPMC10486091 | biostudies-literature
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