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ProteomicsWhole proteome measurement to determine effects of USP7 targeting small molecules in pancreatic cancer cells (Panc89) and melanoma cells (MaMel47)
Whole Proteome measurement of pancreatic cancer cells (Panc89) or melanoma cells (MaMel47) treated with USP7 inhibitors and degrader to compare phenotypes induced by inhibition compared to degradation. We synthesized and characterized potent USP7-targeting degrader molecules (PROTACs) and compared U...
ORGANISM(S): Homo sapiens (Human) 
2026-04-21 | PXD070431 | Pride
Mamel47 Panc89 Lc-ms Usp7-targeting degrader Protac 
GenomicsCDK7 inhibition by LDC4297 in Mia-Paca2 and Panc89 cells
CDK7 inhibition by LDC4297 in Mia-Paca2 and Panc89 cells
PRJNA797431 | ENA
TranscriptomicsCDK7 inhibition by LDC4297 in Mia-Paca2 and Panc89 cells
Inhibition of the dual function cell cycle and transcription kinase CDK7 is known to affect the viability of cancer cells, but the mechanisms underlying cell line-specific growth control remain poorly understood. Here, we employed a previously developed, highly specific small molecule inhibitor that...
ORGANISM(S): Homo sapiens 
2022-01-21 | GSE193737 | GEO
Transcriptomics3' mRNA-seq of human Ma-Mel-47 (melanoma) and Panc89 (PDAC) cells treated with the USP7 degraders NK266 and NK250, respectively, for 72 h.
3' mRNA-seq was used to study the effects of USP7 degradation by the degraders NK266 and NK250 on gene expression in a human melanoma and PDAC cell line, respectively.
ORGANISM(S): Homo sapiens 
2026-03-27 | E-MTAB-16302 | biostudies-arrayexpress
TranscriptomicsEpithelial and mesenchymal pancreatic cancer cells exhibit different stem cell phenotypes being associated with different metastatic propensity
Pancreatic ductal adenocarcinoma (PDAC) is the most common malignant pancreatic tumor in western countries, characterized by a low 5-year survival rate of only 11 %. Owing to a lack of early and specific symptoms, most patients are diagnosed at advanced or even me-tastasized stages essentially impai...
ORGANISM(S): Homo sapiens 
2024-08-14 | GSE241182 | GEO
UnknownEpithelial and Mesenchymal-like Pancreatic Cancer Cells Exhibit Different Stem Cell Phenotypes Associated with Different Metastatic Propensities.
Not available
S-EPMC10886860 | biostudies-literature
Genomics3' mRNA-seq of human Ma-Mel47 (melanoma) and Panc89 (PDAC) cells treated with the USP7 degraders NK250 and NK266, respectively, for 72 h.
3' mRNA-seq of human Ma-Mel47 (melanoma) and Panc89 (PDAC) cells treated with the USP7 degraders NK250 and NK266, respectively, for 72 h.
PRJEB104408 | ENA
UnknownNestin and SOX2 Maintain self-renewal Abilities of Different Pancreatic Cancer Stem Cell Populations.
Not available
S-EPMC12795969 | biostudies-literature
UnknownAntagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma.
Not available
S-EPMC8699468 | biostudies-literature
GenomicsEpithelial and mesenchymal pancreatic cancer cells exhibit different stem cell phenotypes being associated with different metastatic propensity
Epithelial and mesenchymal pancreatic cancer cells exhibit different stem cell phenotypes being associated with different metastatic propensity
PRJNA1006692 | ENA
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