Whole Proteome measurement of pancreatic cancer cells (Panc89) or melanoma cells (MaMel47) treated with USP7 inhibitors and degrader to compare phenotypes induced by inhibition compared to degradation. We synthesized and characterized potent USP7-targeting degrader molecules (PROTACs) and compared U...
Whole proteome measurement to determine selectivity profile for compound NK266 in melanoma as well as determining downstream signalling effects of DUB inhibition and degradation.
