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ProteomicsThe Cryptosporidium signaling kinase CDPK5 plays an important role in male gametogenesis and parasite virulence
The protozoan parasite Cryptosporidium is a leading cause of diarrhea associated mortality in young children. The parasite’s lifecycle involves a highly coordinated and timely progression from asexual proliferative to sexual stages leading to formation of the transmissible oocyst. Underlying molecul...
ORGANISM(S): Cellular Organisms 
2024-06-04 | PXD051082 | JPOST Repository
TranscriptomicsProteomic view of the Plasmodium falciparum life cycle
The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of t...
ORGANISM(S): Plasmodium falciparum 3D7 
2002-12-22 | E-GEOD-92 | biostudies-arrayexpress
ProteomicsNext-generation diagnostic biomarkers for vivax malaria
The global impact of Plasmodium vivax has been largely underestimated for several decades due to lower mortality rates compared to P. falciparum. However, in recent times, the parasite has become a serious threat to public health due to its ability to cause severe malaria with fatal outcomes. Its un...
ORGANISM(S): Plasmodium vivax 
2020-01-30 | PXD015165 | Pride
Multiple reaction monitoring Malaria Parasite Biomarker candidates Q exactive orbitrap Mass spectrometry Diagnosis 
ProteomicsRapid proximity biotinylation of the Plasmodium falciparum exported protein, SBP1
The deadly human malaria-causing parasite, Plasmodium falciparum relies on its capacity to completely remodel its host red blood cell (RBC) through the export of several hundred parasite proteins across several membranes to the RBC.We fused the exported membrane protein, skeleton binding protein 1 (...
ORGANISM(S): Plasmodium Falciparum Nf54 (ncbitaxon:5843) 
2022-06-27 | MSV000089743 | MassIVE
UnknownProteomics Applications in <i>Toxoplasma gondii</i>: Unveiling the Host-Parasite Interactions and Therapeutic Target Discovery.
Not available
S-EPMC10821451 | biostudies-literature
ProteomicsTargeted and non-targeted proteomics to characterize the parasite proteins of Echinococcus multilocularis metacestodes
The larval stage of the cestode Echinococcus multilocularis is the causative agent of alveolar echinococcosis, a lethal disease if untreated. To date, drug treatment options are limited, non-curative and need improvement. In this project we investigated the proteomic composition of in vitro generate...
ORGANISM(S): Echinococcus multilocularis 
2024-07-19 | PXD040274 | Pride
Model system Host-parasite interplay Transport Alveolar echinococcosis Untargeted proteomics Cestodes Targeted proteomics 
UnknownComprehensive proteomics investigation of P. vivax-infected human plasma and parasite isolates.
Not available
S-EPMC7053139 | biostudies-literature
UnknownExploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite.
Not available
S-EPMC7440042 | biostudies-literature
ProteomicsThe mRNA-bound proteome of Leishmania mexicana is stage-regulated with distinct transcript target pools
Leishmania species parasite infections, termed the leishmaniases, cause significant global infectious disease burden. The lifecycle of the parasite embodies three main stages that require precise coordination of gene regulation to survive drastic environmental shifts transitioning from sandfly to ma...
ORGANISM(S): Leishmania Mexicana (ncbitaxon:5665) 
2018-10-11 | MSV000083023 | MassIVE
ProteomicsMudPIT analyses of the chromatin associated proteins isolated from the nucleus of Plasmodium falciparum at three time-points of the intraerythrocytic development cycle
Parasite cultures- Plasmodium falciparum strain 3D7 was cultured in human O+ erythrocytes at 5% hematocrit. Cultures were synchronized at ring stage with 5% (w/v) D-sorbitol treatments. Parasite cultures (8% parasitemia in 5% hematocrit) were harvested 48 hours after the first sorbitol treatment (ri...
ORGANISM(S): Plasmodium Falciparum 3d7 (ncbitaxon:36329) 
2018-06-28 | MSV000082520 | MassIVE
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