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ProteomicsCrosslinking of Ly6a metabolically reprogram CD8 T cells for cancer immunotherapy.
To evaluate the downstream effects of anti-Ly6a crosslinking, we examined the effect of anti-Ly6a antibodies on CD8+ T cell activity in the presence and absence of target tumor cells by high-resolution mass spectrometry proteomic analyses. Spleen cells were isolated from gp10025–33 TCR transgenic mi...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-04 | PXD050734 | Pride
Uvb Cd8 t cells Cancer immunotherapy T cells metabolism 
ProteomicsGolgi-ER Axis Regulates Anti-Tumor T Cell Immunotherapeutic Response
The cumulative role of cellular organelle’s in shaping the life and function of a cell has been long acknowledged. While each organelle plays a specific role in the growth and development of T cells, numerous studies have thus far focused on targeting mitochondria, endoplasmic reticulum, or lysosome...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD048141 | Pride
T cell Golgi apparatus Immunotherapy 
UnknownAXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells.
Not available
S-EPMC10530462 | biostudies-literature
UnknownEffectiveness of Modalities to Teach Evidence Based Medicine to Pediatric Clerkship Students: A Randomized Controlled Trial.
Not available
S-EPMC7525332 | biostudies-literature
UnknownLeukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia.
Not available
S-EPMC8058445 | biostudies-literature
UnknownGM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity.
Not available
S-EPMC9234947 | biostudies-literature
UnknownNaive T cells inhibit the outgrowth of intractable antigen-activated memory T cells: implications for T-cell immunotherapy.
Not available
S-EPMC10124261 | biostudies-literature
UnknownDevelopment of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity.
Not available
S-EPMC9280998 | biostudies-literature
ProteomicsImmunopeptidomic analyses - HLA Export by Melanoma Cells Decoys Cytotoxic T Cells to Promote Immune Evasion
While melanoma cells often express a high burden of mutated proteins, the infiltration of reactive T cells rarely results in tumor-eradicating immunity. We discovered that large extracellular vesicles, known as melanosomes, secreted by melanoma cells are decorated with MHC molecules that stimulate C...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-04-19 | PXD069094 | Pride
Melanoma Melanosomes Immunopeptidome 
UnknownTreatment of Acute Myeloid Leukemia with T Cells Expressing Chimeric Antigen Receptors Directed to C-type Lectin-like Molecule 1.
Not available
S-EPMC5589064 | biostudies-literature
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