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ProteomicsPeptidylarginine deiminase 2 (PADI2) is a key regulator for osteoblast differentiation and bone formation through the maintenance of citrullination-mediated RUNX2 stability
Peptidylarginine deiminase (PADI) 2 catalyzes the posttranslational conversion of peptidyl-arginine to peptidyl-citrulline, a process called citrullination. However, the exact function of PADI2 in bone development and bone homeostasis remains unknown. In this study, we found that Padi2 deficiency le...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040179 | Pride
Citrullination Ptm Padi2 Lc-msms Runx2 
ProteomicsnextPP for chromosome-based proteomic research using neXtProt and GENCODE databases
In this study, we introduce a streamlined pipeline using customized and concatenated GENCODE and neXtProt databases with controlled false discovery rate (FDR) for finding GENCODE ASVs and missing proteins while mapping onto single amino acid variants (SAAVs) from Hippocampal dataset.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-07-25 | MSV000081385 | MassIVE
UnknownDenatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway.
Not available
S-EPMC11660935 | biostudies-literature
UnknownEffects of regulator of G protein signaling 19 (RGS19) on heart development and function.
Not available
S-EPMC2937888 | biostudies-literature
TranscriptomicsPatient specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ (gene expression)
Frequent discrepancies between preclinical and clinical results of anti-cancer agents demand a reliable translational platform that can precisely recapitulate the biology of human cancers. Another critical unmet need is the ability to predict therapeutic responses for individual patients. Toward thi...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-42669 | biostudies-arrayexpress
TranscriptomicsPatient specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ (CGH)
Frequent discrepancies between preclinical and clinical results of anti-cancer agents demand a reliable translational platform that can precisely recapitulate the biology of human cancers. Another critical unmet need is the ability to predict therapeutic responses for individual patients. Toward thi...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-42577 | biostudies-arrayexpress
UnknownSubnanosecond phase transition dynamics in laser-shocked iron.
Not available
S-EPMC7274792 | biostudies-literature
UnknownComparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD.
Not available
S-EPMC9981888 | biostudies-literature
UnknownCoronary Artery Calcification Score and the Progression of Chronic Kidney Disease.
Not available
S-EPMC9342644 | biostudies-literature
UnknownUsing CSF biomarkers to replicate genetic associations in Alzheimer's disease.
Not available
S-EPMC3150628 | biostudies-literature
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