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ProteomicsKetohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
Harmful effects of high fructose intake on health have been widely reported in epidemiological and laboratory studies. Although it has been reported that fructose promotes cancer development and progression, little is known about the underlying molecular mechanisms. Here, we found that fructose trig...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD021035 | Pride
Breast cancer metastasis  fructose  ketohexokinase-a  nuclear translocation  serine kinase 
ProteomicsDifferential quantitative proteome analysis of cerebellar flocculus on oculomotor behavior training mouse model
Oculomotor behavior model system is commonly employed to study the neural circuits and the cellular mechanisms underlying neural integration related to motor behavior. The flocculus is a small lobe at the posterior border of the middle cerebellar and involved in motor control to aid in the oculomoto...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD008433 | Pride
Tmt labeling Flocculus Oculomotor behavior mouse model 
ProteomicsIn-depth quantitative proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, we identified a total of 5497 proteins in whole ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006558 | Pride
Dimethylation labeled quantification Quantitative analysis Bv2 activation 
ProteomicsTargeted proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, using label-free PRM approach which is allowing ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006556 | Pride
Targeted protoemics Quantitative analysis Label-free prm Bv2 activation 
ProteomicsIn-depth characterization of the secretome of mouse CNS cell lines by LC-MS/MS without prefractionation
Microglia, astrocytes, and neurons, which have important functions in the central nervous system, communicate mutually to generate a signal through secreted proteins or small molecules, but many of which have not been identified. Because establishing a reference for the secreted proteins from CNS ce...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001597 | Pride
Neuron Cns cell line Proteome profile Microglia Label-free quantitation Secretome Astrocyte 
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