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TranscriptomicsTranscription profiling of rat heart from rats exposed to Bis(2-chloroethoxy)methane to investigate heart toxicity and recovery in male fisher rats
Specific gene changes after exposure to the heart toxin, bis(2-chloroethoxy)methane, were analyzed to elucidate critical pathways associated with recovery from heart toxicity. Bis(2-chloroethoxy)methane was administered to male F344/N rats at 0, 200, 400, or 600 mg/kg by dermal exposure for up t...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4254 | biostudies-arrayexpress
TranscriptomicsInsulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma
Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; c...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-9600 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression patterns in mouse tissues and staged embryos
RNA from seven adult mouse tissues, four staged whole mouse embryos, ES cells, 3 day and 28 day embryoid bodies was profiled against the microRNA microarray. A custom microarray platform for analysis of microRNA gene expression; Nature Methods 1, 47 - 53 (2004) Keywords = microRNA Keywords = miRN...
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-1635 | biostudies-arrayexpress
TranscriptomicsAn oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27m3 through the genome [RNA-seq]
B-cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2 histone methyltransferase, but the carcinogenic role of these mutations is unclear. Here we describe a mouse model in which the most common somatic EZH2 gain-of-function mutation (Y646F in human, Y641F in the mous...
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-79035 | biostudies-arrayexpress
TranscriptomicsA Supervised Risk Predictor of Breast Cancer Based on Biological Subtypes
Purpose: The biological subtypes of breast cancer designated as Luminal A, Luminal B, HER2+/ER-, and Basal-like are clinically important for prognosis and planning treatment strategies. Recognizing that there is a continuum in both the spectrum of breast cancer disease and the risk of survival, we s...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10886 | biostudies-arrayexpress
TranscriptomicsRNA polymerase is poised for activation across the genome
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA ...
ORGANISM(S): Drosophila melanogaster 
2007-11-11 | E-GEOD-6714 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild-type and TTP-deficient fibroblast cell lines to identify TTP mRNA targets
Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice, and cells derived from them, showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the rates of mRN...
ORGANISM(S): Mus musculus 
2008-11-22 | E-GEOD-5324 | biostudies-arrayexpress
ProteomicsIdentification and Characterisation of Taxonomically Informative Peptides
Hair fibers serve as a prevalent and valuable form of biological trace evidence. Taxonomic classification of hair recovered during a criminal investigation provides crucial forensic intelligence and aids in evidence prioritisation. Traditional classification methods rely heavily on the analysis of h...
ORGANISM(S): Mus musculus (Mouse) Vulpes vulpes (Red fox) Sus scrofa domesticus (domestic pig) Ovis aries Bos taurus (Bovine) Camelus dromedarius (Dromedary) (Arabian camel) Vicugna pacos Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) Felis catus (Cat) (Felis silvestris catus) Canis familiaris (Dog) (Canis lupus familiaris) Cavia porcellus (Guinea pig) Rattus norvegicus (Rat) Capra hircus (Goat) Equus caballus (Horse) 
2026-05-13 | PXD062555 | Pride
Hrms Discovery proteomics Taxonomic classification 
TranscriptomicsGene Expression Profiles of Head and Neck Squamous Cell Carcinoma (HNSCC) primary tumors
60 fresh frozen HNSCC from the University of North Carolina at Chapel Hill (UNC) were obtained from the UNC Tissue Procurement Facility under an IRB approved protocol. 55 tumor samples were collected from the primary tumor and five tumor samples were collected from a local recurrence at the primary ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-686 | biostudies-arrayexpress
ProteomicsDiscordant Fasting Signaling Response in Hearts of Mice with Diet-Induced Obeisity and Insulin Resistance
Sixteen mouse heart samples were analyzed in four groups: Normal, 24hr fast, Diet-Induced Obesity, and DIO with 24hr fast. The cytoplasmic fractions of IN-Sequence heart preparations (solubilized proteins excluding most myofilaments) were analyzed by Liquid Chromatography coupled Mass Spectrometry...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD003345 | Pride
Metabolism Heart Proteomics Mouse Mass spectrometry Ms In-sequence Fvbn Fasting 
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