Sort   by:  
 Page size 
ProteomicsRepeat length of the C9orf72-associated glycine-alanine polypeptides affects their toxicity
G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). G4C2 insertion length is variable, and patients can carry up to several thousand repeats. Dipeptide repeat pro...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-09-12 | PXD038900 | Pride
Toxicity Repeat length Drosophila C9orf72 Glycine-alanine 
ProteomicsProfiling tissue-specific modulation of gene expression in response to insulin signalling in Drosophila
We investigated tissue-specific regulation of gene expression in a long lived Drosophila IIS mutant (dilp2-3,5) compared to its control (wDah). As in the majority of Drosophila laboratory strains, the endosymbiont Wolbachia was present; in the absence of Wolbachia, life extension through dilp2-3,5 i...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-21 | PXD011589 | Pride
Drosophila tissue-specific insulin longevity lifespan aging shotgun 
ProteomicsA proteomic atlas of insulin signaling reveals tissue-specific mechanisms of longevity-assurance
Lowered activity of the insulin/IGF signaling (IIS) network can ameliorate the effects of ageing in model organisms and, possibly, humans. Remodelling of the RNA transcriptome of long-lived IIS mutants has been extensively documented, but is only weakly predictive of consequent changes in protein ex...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2017-09-13 | PXD006225 | Pride
Q exactive Insulin signaling Tissue specific Shotgun Drosophila melanogaster 
ProteomicsInhibition of S6K lowers age-related inflammation and immunosenescence and increases lifespan via the endolysosomal system
The nutrient-sensing Target of Rapamycin complex 1 (TORC1) is an evolutionarily conserved regulator of longevity. S6 kinase (S6K) is an essential downstream mediator for the effect of TORC1 on longevity. However, mechanistic insights on how TORC1-S6K signalling promotes lifespan and healthspan are s...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2024-01-12 | PXD035293 | Pride
Inhibition of s6k lowers age-related inflammation and immunosenescence and increases lifespan via the endolysosomal system 
ProteomicsFunctional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants
Human longevity, coupled to compression of age-related disease, is heritable. However, few common genetic variants have been linked to longevity, suggesting that rare, family-specific variants may also play a role. We therefore investigated whole-genome sequencing data of long-lived families from th...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD063190 | Pride
Longevity Rare variants Functional characterisation Ageing Genetics Mapk/erk signalling pathway 
ProteomicsFull geroprotection from brief rapamycin treatment by persistently increased intestinal autophagy
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid the adverse side-effects of clinical dosing regimes. Here we show a profound memory effect of brief rapamycin treatment. Brief, early adult treatment extended lifespan in Drosophila to the same...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-07-18 | PXD020820 | Pride
Autophagy Fly Tmt Lifespan Drosophila Rapamycin 
TranscriptomicsIntestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
We identified that Drosophila FoxA transcription Fork Head (FKH) function is necessary for reduced insulin signalling and rapamycin induced longevity. Furthermore, we determined that FKH function in the gut tissue alone is sufficient to extend lifespan. We carried out RNA-sequencing in gut tissue o...
ORGANISM(S): Drosophila melanogaster 
2017-09-23 | E-MTAB-6056 | biostudies-arrayexpress
TranscriptomicsEffect of Lithium on Abeta utilising microarray analyses
Our previous work in a Drosophila model of Alzheimer's disease (AD) has shown that we can intervene into the pathways to slow or prevent AD progression. Lithium was able to rescue toxicity in the Drosophila AD model which corresponded with a reduction in Abeta levels. Furthermore, we have demonstra...
ORGANISM(S): Drosophila melanogaster 
2017-01-26 | E-MTAB-4611 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of four mouse tissues following acute caloric restriction
Multi-tissue transcriptional response following acute caloric restriction in mice.
ORGANISM(S): Mus musculus 
2007-05-17 | E-MEXP-748 | biostudies-arrayexpress
Sort   by:  
 Page size