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ProteomicsS100A3 binds directly to RARα and the PML-RARα onco-protein modulating their stability and activit
We defined the RARα interactome in the MDA-MB453 breast cancer cell line genetically engineered to over-express an N-terminally tagged version of the nuclear retinoic acid receptor. Twenty eight nuclear proteins which interact with RARα and whose interaction is stimulated or reduced by the pan-RAR ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD008761 | Pride
Raralpha Silac Interactome 
ProteomicsGeneration of fibronectin fragments by pancreatic trypsin: a physiological mechanism hampering PDAC progression.
In this study we demonstrate that spheroids isolated from normal pancreas and co-trasplanted with PDAC orthotopically in mouse pancreas , inhibited tumor growth. Fibronectin proteolytic fragments generated by trypsin and released by pancreatic spheroids, were responsible for of the observed effect. ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035770 | Pride
Pdac Trypsin Fibronectin Fgfr Fak 
ProteomicsLabel Free proteomics on NSCLC isogenic cell lines
Since both KRAS mutations and LKB1 inactivating alterations affect cellular metabolism, it seems propitious to discern metabolic effects induced by the single oncogenic events from those elicited by their co-occurrence, with the ultimate aim to potentially exploit metabolic depende...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD007838 | Pride
Protepmics kras mutation lkb1 deletion 
ProteomicsDistinct features of plasma extracellular vesicles in amyotrophic lateral sclerosis patients
Extracellular vesicles (EVs) are nanostructures that are used as sources of biomarkers. To better understand whether EVs could be exploited as diagnostic and prognostic biomarkers in Amyotrophic Lateral Sclerosis (ALS), we analyzed plasma-derived of ALS patients and relative healthy and diseased con...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020629 | Pride
Plasma extracellular vesicles and als 
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