Patient-derived xenograft

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Unknown (3834)
Genomics (1853)
Transcriptomics (946)
Proteomics (186)
Other (51)
Methylation profiling (33)
Metabolomics (16)
Genomic (5)
Clinical (2)

Organisms

Homo sapiens (1473)
Mus musculus (132)
Homo sapiens (103)
Mus musculus (103)
Schizosaccharomyces pombe (102)
Oryza sativa Indica Group (102)
Sinorhizobium meliloti BL225C (102)
Sus scrofa domesticus (102)
Saccharomyces cerevisiae (102)
Staphylococcus aureus (102)
Rattus norvegicus (102)
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Physcomitrium patens (102)
Methylohalobius crimeensis 10Ki (102)
Shigella flexneri (102)
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Allexis (102)
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Zea mays (102)
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Canis lupus familiaris (3)
Homo sapiens/Mus musculus xenograft (2)
synthetic construct (2)
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Mus (1)
Drosophila melanogaster (1)
Fusarium sinicum (1)

Organisms

Homo sapiens (1041)
Mus musculus (69)
Homo sapiens/Mus musculus xenograft (2)
Canis lupus familiaris (2)
Cancer sp. (1)
human viral metagenome (1)
Mammalia (1)
Mus (1)
Danio rerio (1)

Repository

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geo (948)
EGA (348)
biostudies-arrayexpress (235)
pride (103)
MassIVE (39)
iProX (27)
MetaboLights (15)
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dbGaP (5)
jPOST (5)
GPMDB (2)
PanoramaPublic (2)
GNPS (1)
PAXDB (1)

Tissue

Cell culture (32)
Breast (9)
Epithelial cell (8)
Brain (7)
Permanent cell line cell (5)
B cell (4)
Bone marrow (3)
Lung (3)
Liver (3)
Bile duct (2)
Melanoma cell (2)
Primary cell line cell (2)
Breast cancer cell (2)
Epithelial cell of lung (2)
Melanocyte (2)
Primary cell (2)
Leukocyte (2)
Blood cell (2)
Stem cell (2)
Myeloid cell (2)
Hepatocyte (2)
Cholangiocarcinoma cell line (1)
Small cell lung cancer cell (1)
B-cell lymphoma/leukemia 11B (1)
Breast cancer stem cell (1)
Multiple myeloma cell line (1)
TEX cell (1)
MOLM-14 cell (1)
MV-4-11 cell (1)
MOLM-16 cell (1)

Disease

Breast cancer (19)
Malignant neoplasm of ovary (8)
Acute leukemia (8)
Brain glioblastoma multiforme (7)
Melanoma (5)
Lung cancer (5)
Cholangiocarcinoma (3)
Brain cancer (3)
Colon cancer (3)
Not Available (2)
Merkel cell carcinoma (2)
Hepatocellular carcinoma (2)
Neuroblastoma (2)
Carcinoma (1)
Neoplasms (1)
Luminal breast carcinoma (1)
B-cell acute lymphoblastic leukemia (1)
Myxoid liposarcoma (1)
Diffuse midline glioma (1)
Vascular cancer (1)
Bladder carcinoma (1)
Triple-receptor negative breast cancer (1)
Oral squamous cell carcinoma (1)
Pancreatic ductal carcinoma (1)
B-cell lymphoma (1)
Non-small cell lung carcinoma (1)
Diffuse gastric cancer (1)
Medulloblastoma (1)
Neck carcinoma (1)
Head and neck squamous cell carcinoma (1)

Technology Type

Mass Spectrometry (103)
Shotgun proteomics (52)
Bottom-up proteomics (27)
Affinity purification coupled with mass spectrometry proteomics (16)
Data-dependent acquisition (12)
Mass spectrometry assay (9)
Data-independent acquisition (8)
Mass spectrometry (6)
Illumina HiSeq 2000 (4)
Fluorescence intensity (4)
Fluorescence imaging (4)
Top-down proteomics (4)
Mass spectrometry (3)
Gel-based experiment (3)
Illumina HiSeq 2000, ILLUMINA (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
Infinium_OmniExpress-24v1.0 (1)
ABI_SOLID, Illumina HiSeq 2000, Illumina 450K, AB 5500xl Genetic Analyzer, AB 5500 Genetic Analyzer, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 4000, Illumina HiSeq 2500 (1)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2500, ILLUMINA (1)
Illumina HiSeq 2000, Illumina MiSeq (1)
ILLUMINA, Illumina HiSeq 2000 (1)
RNA-seq (1)
DNA sequencing (1)
Proteogenomics (1)
RNA mass spectrometry (1)
SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Orbitrap Fusion Lumos (12)
Illumina HiSeq 2000 (10)
Q Exactive (10)
Illumina HiSeq 4000 (9)
Illumina HiSeq 2500 (8)
Illumina NovaSeq 6000 (8)
NextSeq 500 (8)
NextSeq 550 (5)
LTQ Orbitrap Elite (4)
Orbitrap Exploris 480 (4)
Q Exactive Plus (3)
Q Exactive HF (3)
Instrument (2)
Orbitrap Exploris 240 (2)
Illumina Hybridisation Oven (1)
10x Chromium Controller (1)
MoFlo Legacy cell sorter (Beckman Coulter) (1)
PC (1)
Qiagen MinElute (1)
Illumina iScan (1)
BD FACSARIA II (1)
Affymetrix GeneChip Scanner 3000 (1)
GeneChip Scanner 3000 7G (1)
Illumina Genome Analyzer IIx (1)
Illumina NovaSeq X (1)
QE-HF-x (1)
TimsTOF HT (1)
LTQ Velos (1)
ZenoTOF 7600 (1)
LTQ Orbitrap XL (1)

Publication Date

2025 (184)
2026 (179)
2023 (153)
2024 (145)
2021 (112)
2022 (111)
2020 (77)
2015 (73)
2016 (64)
2019 (62)
2018 (61)
2014 (56)
2017 (29)
2013 (23)
2012 (17)
2011 (10)
2010 (8)
2008 (4)
2009 (2)
2005 (1)
2027 (1)

UNIPROT ID/AC

CCD70_HUMAN (1)
F228A_HUMAN (1)
NTM2B_HUMAN (1)
KLF17_HUMAN (1)
ENPP3_HUMAN (1)
CAPSL_HUMAN (1)
SETBP_HUMAN (1)
FGF22_HUMAN (1)
OR8B2_HUMAN (1)
CAD15_HUMAN (1)
SVOPL_HUMAN (1)
ZN862_HUMAN (1)
ZBT41_HUMAN (1)
FUT2_HUMAN (1)
PRR5L_HUMAN (1)
OR5DE_HUMAN (1)
CKLF1_HUMAN (1)
P12L2_HUMAN (1)
MPIP2_HUMAN (1)
SH24B_HUMAN (1)
NETR_HUMAN (1)
MKX_HUMAN (1)
F228B_HUMAN (1)
NTM2A_HUMAN (1)
O51B2_HUMAN (1)
SHSA2_HUMAN (1)
HDX_HUMAN (1)
TRPM5_HUMAN (1)
TC1D4_HUMAN (1)
FBX48_HUMAN (1)

CHEBI ID

CHEBI:61040 (1)
CHEBI:183109 (1)
CHEBI:37755 (1)
CHEBI:183608 (1)
CHEBI:176456 (1)
CHEBI:89312 (1)
CHEBI:145755 (1)
CHEBI:191252 (1)
CHEBI:133649 (1)
CHEBI:133647 (1)
CHEBI:137271 (1)
CHEBI:84153 (1)
CHEBI:19928 (1)
CHEBI:191640 (1)
CHEBI:165864 (1)
CHEBI:86348 (1)
CHEBI:45658 (1)
CHEBI:142440 (1)
CHEBI:77042 (1)
CHEBI:166485 (1)
CHEBI:165856 (1)
CHEBI:133515 (1)
CHEBI:75038 (1)
CHEBI:78266 (1)
CHEBI:78261 (1)
CHEBI:74977 (1)
CHEBI:133672 (1)
CHEBI:75062 (1)
CHEBI:17985 (1)
CHEBI:73070 (1)

Metabolite Name

LPE(P-16:0) (2)
LPC(17:0/0:0) (2)
1-Methylhistidine (2)
N1-Methyl-4-pyridone-3-carboxamide (2)
SM(d18:1/18:0) (2)
Creatine (2)
Anserine (2)
Glycine (2)
2-Aminobutyric acid (2)
2'-O-methylcytidine (2)
LPC(18:0/0:0) (2)
LPC(18:2/0:0) (2)
Kynurenine (2)
[(Aminocarbonyl)(methyl)amino]acetic acid (1)
2-(2-Aminoethoxy)acetic acid (1)
2-Amino-3-methyl-imidazo[4,5-f]quinoline (IQ) (1)
Unkown (1)
Cytidine 2',3'-cyclic monophosphate (1)
Oxotetradecadienoylcarnitine (Car(14:3-O)) (1)
Picoline (1)
Bicine (1)
Hexenoylcarnitine (Car(6:1)) (1)
4-(Dimethylamino)pyridine (1)
Physoperuvine (1)
Arsenobetaine (1)
¦Á-Aminoadipic acid (1)
L-Tryptophyl-L-glutamic acid (1)
N¦Á-Acetyl-L-glutamine (1)
Creatine Phosphate (1)
L-¦Á-Aspartyl-L-phenylalanine (1)

First Public Date

2026 (216)
2025 (214)
2024 (193)
2023 (161)
2022 (120)
2021 (101)
2020 (86)
2019 (75)
2018 (47)
2015 (43)
2014 (40)
2017 (36)
2016 (20)
2013 (3)

Modification

-17.026549 (1)
42.010565 (1)
15.994915 (1)

Study status

Recruiting (2)

Study type

Transcription profiling by array (130)
RNA-seq of coding RNA (40)
Methylation profiling by array (13)
Genotyping by array (7)
Comparative genomic hybridization by array (7)
ChIP-seq (7)
Human - High-throughput sequencing (4)
Cell line - High-throughput sequencing (3)
RNA-seq of coding RNA from single cells (3)
RNA-seq of non coding RNA (3)
Unknown experiment type (2)
Human - One-color microarray (2)
ATAC-seq (2)
DNA-seq (2)
Proteomic profiling by array (2)
Methylation profiling by high throughput sequencing (2)
Observational (2)
Human - Methylation microarray (1)
RNAi profiling by array (1)
Transcription profiling by RT-PCR (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

2025 (527)
2022 (460)
2023 (450)
2021 (440)
2024 (419)
2020 (382)
2019 (312)
2018 (251)
2017 (205)
2016 (194)
2015 (155)
2014 (87)
2026 (81)
2013 (37)
2011 (21)
2012 (20)
2010 (13)
2009 (4)
2008 (4)
2005 (1)
2007 (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (6)
Cancer Biology Department, Fox Chase Cancer Center, Philadelphia, PA, USA (3)
Baylor College of Medicine (3)
Memorial Sloan Kettering Cancer Center (3)
Johns Hopkins University (2)
Cancer Signalling Research Group, School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA. (1)
Proteomics Core Facillity, Biozentrum, University of Basel 4056 Basel, Switzerland (1)
University of Newcastle, Callaghan, NSW, Australia (1)
Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria (1)
Proteomics Platform CIC bioGUNE Bizkaia Tech. Park Build. 800 48160 Derio Spain (1)
Charles E. Foulds, Ph.D. Assistant Professor Lester and Sue Smith Breast Center Baylor College of Medicine (1)
Department of Pharmacology University of Colorado Anschutz Medical Campus (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (1)
INSERM U1029, University Bordeaux, Pessac, France (1)
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States (1)
Professor, Human Biology, Fred Hutchinson Cancer Center, USA (1)
The First Affiliated Hospital of Jinan University (1)
Department of Systems Biology, City of Hope Comprehensive Cancer Center, CA, USA (1)
Dana-Farber Cancer Institute 450 Brookline Avenue Boston, MA 02215 USA (1)
Proteomics and Cancer Cell Signaling Unit, German Cancer Research Center, Heidelberg,Germany (1)
Senior Group Leader (1)
Department of Physiology & Biophysics University of California, Irvine (1)
Immunology Department, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (1)
Senior group Leader (1)
Proteomics Platform, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany (1)
Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu. Esplugues de Llobregat, 08950 Barcelona, Spain (1)
The Jackson Laboratory For Genomic Medicine (1)
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), School of Life Sciences, University of Dundee, Dundee, UK (1)
Department of Human Structure and Repair, Laboratory of Experimental Cancer Research, Ghent University, Belgium3. Cancer Research Institute Ghent (CRIG), Ghent University, Belgium (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (1)

Location

Canada (1)
France (1)

Keyword

Personalized patient-derived xenografts (pPDX) (1)
Drug sensitivity testing (1)
Serous (1)
Triple negative (1)
Metastatic (1)
Molecular profiling (1)
Epigenetic analysis (1)

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Medulloblastoma Patient-Derived Xenograft Proteomics

Proteomic and phosphoproteomic characterization of 20 orthotopic patient-derived xenograft models of medulloblastoma

ORGANISM(S): Homo sapiens (Human)

2022-09-01 | PXD035070 | Pride

A platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...

ORGANISM(S): Homo sapiens

2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress

Genomic profiling of patient-derived xenografts identify high level â€œpassengerâ€ gene aberrations associated with better prognosis in non-small cell lung cancer

Patient-derived tumor xenografts (PDXs) increasingly are being used as preclinical models to study human cancers and to evaluate novel therapeutics, as they reflect clinical cancers more closely than established tumor cell lines. With >100 PDXs established from resected non-small cell lung carcinoma...

ORGANISM(S): Mus musculus

2016-10-26 | E-GEOD-68929 | biostudies-arrayexpress

Using a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance.

Original patient tumor is directly implanted in mice xenografts. Tumor is propagated to multiple mice for conduct of 6 arm treatment trials and control. Therapies are selected based on T0 and F0 genomic profiles. ICE-T refractory tumor are implanted and additional 6 arm treatment trial and control c...

ORGANISM(S): Homo sapiens

2014-07-22 | E-GEOD-51130 | biostudies-arrayexpress

Identification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse

Personalized cancer immunotherapy targeting patient-specific cancer/testis (CTA) antigens and neoantigens may benefit from large-scale tumor HLA peptidome (immunopeptidome) analysis, which aims to accurately identify antigens presented by tumor cells. While significant efforts have been invested in ...

ORGANISM(S): Homo sapiens (Human)

2020-05-27 | PXD016060 | Pride

Patient derived xenograft Tumor antigen Peptidome Hla

Of mice and models: Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer

- Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, whi...

ORGANISM(S): Homo sapiens (Human)

2025-04-07 | PXD054649 | Pride

Proteogenomics Proteomics Mass spectrometry Patient-derived xenograft models (pdx) Ovarian cancer

Construction of GBM patient-derived xenograft mouse models

PRJNA857591 | ENA

Proteomic profiling of AML patient-derived xenografts across serial transplantation

This dataset contains mass spectrometry-based proteomic profiling of acute myeloid leukemia patient-derived xenograft samples collected across serial transplantation stages. The study aimed to characterize proteome remodeling associated with leukemia propagation and disease evolution in AML PDX mode...

ORGANISM(S): Homo sapiens (Human)

2026-07-20 | PXD078079 | Pride

Acute myeloid leukemia aml patient-derived xenograft pdx serial transplantation proteomics mass spectrometry leukemia stem cells

Whole DNA methylome of an extramedullary multiple myeloma patient derived orthotopic xenograft

A patient derived orthotopic xenograft (PDOX) was generated from a patient with an 53 aggressive extramedullary multiple myeloma (EMM) to study in-depth genetic and epigenetic events and drug responses related to extramedullary disease. Whole DNA methylome of the EMM PDOX was also evaluated and comp...

ORGANISM(S): Homo sapiens

2021-06-25 | E-MTAB-10654 | biostudies-arrayexpress

RNA-Seq of patient derived osteosarcoma xenograft samples

PRJNA513353 | ENA

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