Patient-derived xenograft (pdx)

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Unknown (1510)
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Organisms

Homo sapiens (514)
Homo sapiens (64)
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Mus (1)
synthetic construct (1)

Organisms

Homo sapiens (503)
Mus musculus (26)
Homo sapiens/Mus musculus xenograft (2)
Canis lupus familiaris (2)
human viral metagenome (1)
Mus (1)

Repository

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Tissue

Cell culture (17)
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Disease

Breast cancer (14)
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Medulloblastoma (1)
Melanoma (1)
Merkel cell carcinoma (1)
Myxoid liposarcoma (1)
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Neuroblastoma (1)
Non-small cell lung carcinoma (1)
Oral squamous cell carcinoma (1)
Pancreas adenocarcinoma (1)
Pancreatic ductal carcinoma (1)
Stomach carcinoma (1)

Technology Type

Mass Spectrometry (64)
Shotgun proteomics (34)
Bottom-up proteomics (18)
Affinity purification coupled with mass spectrometry proteomics (9)
Data-dependent acquisition (8)
Mass spectrometry (4)
Data-independent acquisition (4)
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Mass spectrometry assay (3)
Illumina HiSeq 2000, ILLUMINA (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
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ILLUMINA, Illumina HiSeq 2000 (1)
Gel-based experiment (1)
Proteogenomics (1)
SRM/MRM (1)

Instrument Platform

Q Exactive (7)
Illumina NovaSeq 6000 (6)
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Illumina HiSeq 4000 (6)
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NextSeq 500 (4)
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Liquid Chromatography MS - alternating - hilic (2)
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Liquid Chromatography MS - positive - hilic (2)
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10x Chromium Controller (1)
MoFlo Legacy cell sorter (Beckman Coulter) (1)
PC (1)
Qiagen MinElute (1)
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BD FACSARIA II (1)
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6560 Q-TOF LC/MS (1)
LTQ Orbitrap Elite (1)
Orbitrap Eclipse (1)
Orbitrap Exploris 480 (1)
Orbitrap Fusion (1)
Q Exactive HF (1)
Liquid Chromatography MS - negative (1)
Liquid Chromatography MS - positive (1)
Liquid Chromatography MS - negative - reverse-phase (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2026 (78)
2025 (75)
2024 (74)
2023 (71)
2021 (58)
2022 (52)
2020 (41)
2015 (28)
2019 (27)
2016 (25)
2018 (19)
2017 (15)
2014 (10)
2013 (4)
2011 (1)

CHEBI ID

CHEBI:61040 (1)
CHEBI:191252 (1)
CHEBI:133649 (1)
CHEBI:133647 (1)
CHEBI:183608 (1)
CHEBI:188969 (1)
CHEBI:39065 (1)
CHEBI:190598 (1)
CHEBI:142440 (1)
CHEBI:17586 (1)
CHEBI:166485 (1)
CHEBI:193556 (1)
CHEBI:132546 (1)
CHEBI:191640 (1)
CHEBI:183109 (1)
CHEBI:137271 (1)
CHEBI:145755 (1)
CHEBI:165864 (1)
CHEBI:70961 (1)
CHEBI:133032 (1)
CHEBI:168338 (1)
CHEBI:177395 (1)
CHEBI:73051 (1)
CHEBI:15873 (1)
CHEBI:133460 (1)
CHEBI:21440 (1)
CHEBI:25013 (1)
CHEBI:165856 (1)
CHEBI:32812 (1)
CHEBI:172453 (1)

Metabolite Name

Kynurenine (2)
¦Á-Aminoadipic acid (1)
Creatine Phosphate (1)
L-¦Á-Aspartyl-L-phenylalanine (1)
(S)-¦Â-Aminoisobutyric Acid (1)
(5-L-Glutamyl)-L-Alanine (1)
Argininosuccinic acid (1)
L-Tryptophyl-L-glutamic acid (1)
¦Ã-Glutamate-Cysteine (1)
Glycylphenylalanine (1)
S-(5-Adenosyl)-L-Homocysteine (1)
5-Hydroxy-Tryptamine (1)
Cyano-alanine (1)
L-tyrosine methyl ester (1)
N¦Á-Acetyl-L-glutamine (1)
3-N-Methyl-L-Histidine (1)
3-Iodo-L-Tyrosine (1)
1,3,7-Trimethyluric Acid (1)
N¦Á-Acetyl-L-Arginine (1)
Nicotinuric Acid (1)
4-Acetamidobutyric Acid (1)
Unkown (1)
D-Alanyl-D-Alanine (1)
Stearoylcholine* (1)
Phosphorylethanolamine (1)
Isoleucylhydroxyproline* (1)
Leucylhydroxyproline* (1)
Hydroxyasparagine** (1)
Dimethyl sulfone (1)
Gamma-glutamyltryptophan (1)

First Public Date

2026 (102)
2024 (102)
2025 (91)
2023 (75)
2022 (63)
2021 (56)
2020 (51)
2019 (40)
2018 (22)
2017 (19)
2015 (17)
2016 (15)
2014 (8)

Modification

-17.026549 (1)
15.994915 (1)
42.010565 (1)

Study status

Recruiting (1)

Study type

Transcription profiling by array (29)
RNA-seq of coding RNA (22)
Human - High-throughput sequencing (4)
Methylation profiling by array (4)
RNA-seq of coding RNA from single cells (3)
Genotyping by array (2)
Unknown experiment type (1)
Human - One-color microarray (1)
Cell line - High-throughput sequencing (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
Comparative genomic hybridization by array (1)
ATAC-seq (1)
ChIP-seq (1)
Proteomic profiling by array (1)
RNA-seq of total RNA (1)
RNA-seq of non coding RNA (1)
Observational (1)

Release Date

2025 (206)
2022 (195)
2021 (192)
2023 (191)
2020 (178)
2024 (169)
2019 (133)
2018 (89)
2017 (75)
2016 (62)
2015 (43)
2026 (32)
2014 (16)
2013 (3)
2011 (1)

Lab affiliation

Baylor College of Medicine (3)
Cancer Biology Department, Fox Chase Cancer Center, Philadelphia, PA, USA (3)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Johns Hopkins University (2)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Breast Center - Lewis, Baylor College of Medicine, Houston TX US (1)
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA (1)
Cancer Signalling Research Group, School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA. (1)
Charles E. Foulds, Ph.D. Assistant Professor Lester and Sue Smith Breast Center Baylor College of Medicine (1)
Clinical Research Division, Fred Hutchinson Cancer Research Center (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Department of Biology II and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany (1)
Department of Biology, Technion–Israel Institute of Technology Haifa, Israel (1)
Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (1)
Department of Laboratory Medicine and Pathology, University of Minnesota (1)
Department of Medical Biotechnology and Laboratory Science College of Medicine, Chang Gung University, Taoyuan, Taiwan (1)
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States (1)
Department of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, Buffalo, New York, United States (1)
Department of Physiology & Biophysics University of California, Irvine (1)
Department of Systems Biology, City of Hope Comprehensive Cancer Center, CA, USA (1)
Division of Oncology and Pathology, Dept. of Clinical Sciences Lund, Lund University, Lund, Sweden (1)
German Cancer Reseach Center (DKFZ) (1)
Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000 Leuven, Belgium / Department of Obstetrics and Gynecology, University Hospitals Leuven and Department of Oncology, 3000 Leuven, Belgium / Centre for Gynecologic Oncology Amsterdam (CGOA), Antoni Van Leeuwenhoek-Netherlands Cancer Institute (AvL-NKI), University Medical Center (UMC), Amsterdam, The Netherlands (1)
Head of the Curie Institute Mass Spectrometry Platform (1)
Hospital for Sick Children, Toronto, Ontario, Canada (1)
INSERM U1231 Center of translational and molecular medicine Université de Bourgogne 7 Bd Jeanne d'Arc, 21000 DIJON (1)
Immunology Department, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (1)
Indiana University School of Medicine, Dept of Pediatrics; Herman B Wells Center for Pediatric Research (1)

Location

France (1)

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Genomic profiling of patient-derived xenografts identify high level â€œpassengerâ€ gene aberrations associated with better prognosis in non-small cell lung cancer

Patient-derived tumor xenografts (PDXs) increasingly are being used as preclinical models to study human cancers and to evaluate novel therapeutics, as they reflect clinical cancers more closely than established tumor cell lines. With >100 PDXs established from resected non-small cell lung carcinoma...

ORGANISM(S): Mus musculus

2016-10-26 | E-GEOD-68929 | biostudies-arrayexpress

Identification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse

Personalized cancer immunotherapy targeting patient-specific cancer/testis (CTA) antigens and neoantigens may benefit from large-scale tumor HLA peptidome (immunopeptidome) analysis, which aims to accurately identify antigens presented by tumor cells. While significant efforts have been invested in ...

ORGANISM(S): Homo sapiens (Human)

2020-05-27 | PXD016060 | Pride

Medulloblastoma Patient-Derived Xenograft Proteomics

Proteomic and phosphoproteomic characterization of 20 orthotopic patient-derived xenograft models of medulloblastoma

ORGANISM(S): Homo sapiens (Human)

2022-09-01 | PXD035070 | Pride

Proteomics Medulloblastoma Phosphoproteomics Patient-derived xenograft (pdx) Lc-ms/ms

Using a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance.

Original patient tumor is directly implanted in mice xenografts. Tumor is propagated to multiple mice for conduct of 6 arm treatment trials and control. Therapies are selected based on T0 and F0 genomic profiles. ICE-T refractory tumor are implanted and additional 6 arm treatment trial and control c...

ORGANISM(S): Homo sapiens

2014-07-22 | E-GEOD-51130 | biostudies-arrayexpress

Of mice and models: Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer

- Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, whi...

ORGANISM(S): Homo sapiens (Human)

2025-04-07 | PXD054649 | Pride

Proteogenomics Proteomics Mass spectrometry Patient-derived xenograft models (pdx) Ovarian cancer

RNAseq analysis of SCLC PDX models

We investigated the gene expression changes in a library of small cell lung carcinoma (SCLC) patient-derived xenograft (PDX) models.

ORGANISM(S): Homo sapiens

2022-02-07 | E-MTAB-11230 | biostudies-arrayexpress

Transcriptomic analysis of sotorasib-resistant patient-derived xenograft (PDX) lung tumor cells

PRJNA842089 | ENA

RNA-Seq of ALDH positive and ALDH negative cells from patient-derived xenograft models of colon cancer

Colon cancer patient-derived xenograft (PDX) models were processed to single cells and sorted by FACS (BD FACS Aria II) for ALDH activity (Aldefluor assay) and DAPI. ALDH Negative and ALDH Positive cells from each PDX model were collected and lysed in RLT buffer and processed for RNA using the RNeas...

ORGANISM(S): Homo sapiens

2021-01-11 | E-MTAB-8927 | biostudies-arrayexpress

Whole transcriptome profiling of 79 patient derived xenograft (PDX) models

RNA-Seq and a species-specific mapping strategy were used to profile the human and mouse transcriptomes of tumour samples taken from 79 PDX models representing multiple cancer types (19 x breast, 37 x lung, 8 x colorectal, 7 x ovarian, 3 x endometrial, 2 x pancreatic, 2 x ampullary, 1 x leukaemia).

ORGANISM(S): Mus musculus

2016-03-01 | E-MTAB-3980 | biostudies-arrayexpress

Proteomic profiling of AML patient-derived xenografts across serial transplantation

This dataset contains mass spectrometry-based proteomic profiling of acute myeloid leukemia patient-derived xenograft samples collected across serial transplantation stages. The study aimed to characterize proteome remodeling associated with leukemia propagation and disease evolution in AML PDX mode...

ORGANISM(S): Homo sapiens (Human)

2026-07-20 | PXD078079 | Pride

Acute myeloid leukemia aml patient-derived xenograft pdx serial transplantation proteomics mass spectrometry leukemia stem cells

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