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ProteomicsChronic shisha exposure alters phosphoproteome of oral keratinocytes
Shisha smoking has been epidemiologically linked to development of oral lesions as well as various cancers. However, few molecular studies investigate the pathobiology of shisha induced cancer. In this study we investigate the effects of chronic shisha exposure in an in vitro model using normal, imm...
ORGANISM(S): Homo sapiens (Human) 
2019-07-23 | PXD011318 | Pride
Oral cancer Hookah Waterpipe tobacco smoking Narghile tobacco Carcinogenesis High-throughput Oscc Orbitrap fusion 
ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke in oral keratinocytes
Smoking is the leading cause of preventable death worldwide. It increases the risk for various diseases including respiratory diseases, vascular diseases and different cancers including lung, oral and bladder cancer. Despite being the leading cause of oral cancer, the molecular mechanisms resulting ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-05 | PXD007637 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
ProteomicsProteomic analysis of oral keratinocytes chronically exposed to shisha
Shisha smoking is widely believed to be a hazard-free habit. Studies have reported shisha smoking to be associated with oral lesions as well ascarcinomas of the lung, esophagus, bladder, and pancreas. A better understanding of the underlying mechanism may contribute to the identification of biomarke...
ORGANISM(S): Homo sapiens (Human) 
2019-02-21 | PXD011106 | Pride
Immune response Interferon pathway Proteomics Oxidative stress In vitro cellular model 
ProteomicsTargeting Focal Adhesion Kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of Epidermal Growth Factor Receptor
Cigarette smoking is the leading cause for non-small cell lung carcinoma (NSCLC). Tyrosine kinase inhibitors (TKIs) targeting EGFR are in clinical practice and has benefitted patients with EGFR mutations. However, EGFR based targeted therapies have shown limited success in smokers. Identification of...
ORGANISM(S): Homo sapiens (Human) 
2018-03-21 | PXD006705 | Pride
Epidermal growth factor receptor Drug resistance Nsclc Cigarette smoke Phosphoproteomics 
UnknownMAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma.
Not available
S-EPMC6906491 | biostudies-literature
UnknownCigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes.
Not available
S-EPMC5935709 | biostudies-literature
UnknownRole of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells.
Not available
S-EPMC6235782 | biostudies-literature
UnknownChronic Exposure to Chewing Tobacco Induces Metabolic Reprogramming and Cancer Stem Cell-Like Properties in Esophageal Epithelial Cells.
Not available
S-EPMC6770059 | biostudies-literature
ProteomicsMm_IL-33_Phospho_Silac
Mouse Quantitative phosphoproteomic analysis of IL-33 mediated signaling
ORGANISM(S): Mus Musculus 
2015-12-31 | PAe005214 | PeptideAtlas
Proteomics,MultiomicsA draft map of the human proteome
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here, we report a draft map of the human proteome based on high resolution Fouri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-16 | MSV000079514 | MassIVE
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