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ProteomicsThe Arabidopsis Mediator complex subunit 8 regulates oxidative stress responses
Hydrogen peroxide (H2O2) signals regulate plant growth and defense by orchestrating genome-wide transcriptional re-programming, however, the specific mechanisms that regulate H2O2-dependent gene expression are poorly understood. Here we report the identification of the Mediator complex subunit MED8 ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-09-17 | PXD016615 | Pride
Arabidopsis Mediator complex Catalase Oxidative stress Med8 Hydrogen peroxide 
ProteomicsTreating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Conditioned Medium]
Hypoxia-related pregnancy complications increase the risk of disease in the child in later life. No prevention is available. Previously we noted that a trophoblast barrier, an in vitro model of the placenta, reacted to oxidative stress by secreting factors that damage neighbouring cells. Application...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-08-22 | PXD004956 | Pride
Pregnancy Placenta Oxidative stress Mitoq Fetal development Nanoparticles Hypoxia 
ProteomicsTreating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Fetal Plasma]
Hypoxia-related pregnancy complications increase the risk of disease in the child in later life. No prevention is available. Previously we noted that a trophoblast barrier, an in vitro model of the placenta, reacted to oxidative stress by secreting factors that damage neighbouring cells. Application...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-08-22 | PXD004955 | Pride
Oxidative stress Placenta Mitoq Fetal development Blood Pregnancy Plasma Hypoxia Nanoparticles 
TranscriptomicsIdentification of Biologically Relevant Enhancers in Human Erythroid Cells [Illumina BeadArray]
Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypo...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43624 | biostudies-arrayexpress
GenomicHispanic Lupus GWAS_HISPSLEI Study

The study comprises SLE patients recruited from specialist rheumatology clinics from the United States, Mexico, Argentina, Chile and Peru. Two strategies were used to enrich samples for Native American ancestry: a. previously genotyped Hispanic and Latin American and US Native American individual...

phs001025 | dbGaP
GenomicsIdentification of Biologically Relevant Enhancers in Human Erythroid Cells [ChIP-Seq]
Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypo...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43625 | biostudies-arrayexpress
ProteomicsPig Serum Proteome during Conventional and Extracorporeal Resuscitation
Pigs underwent 5 min of untreated cardiac arrest followed by 8 min of basic life support and 22 min of advanced life support (ALS). Following this conventional cardiopulmonary resuscitation, all pigs were treated 120 min with extracorporeal circulation (eCPR). Blood samples were drawn at baseline, a...
ORGANISM(S): Sus Scrofa (ncbitaxon:9823) 
2021-12-21 | MSV000088595 | MassIVE
TranscriptomicsA key role for a glutathione transferase in multiple herbicide resistance in grass weeds
The gene encoding a protein (AmGSTF1) associated with multiple herbicide resistance (MHR) in black-grass was transgenically expressed in Arabidopsis thaliana.The goal of this study was to determine if AmGSTF1 could elicit an MHR phenotype in the transgenic host. Affymetix microarrays were used to de...
ORGANISM(S): Arabidopsis thaliana 
2013-03-13 | E-GEOD-42065 | biostudies-arrayexpress
GenomicsPD
WTCCC project samples from the Parkinson's disase cohort
EGAD00000000057 | EGA
GenomicsGenome wide association scan in Parkinson's disease
Genome-wide association scan was performed in 1,705 cases of parkinson's genotyped on the Illumina Human 660W SNP array, and 5,175 controls genotyped on the Illumina1.2M-Duo. Analysis was carried out on the overlaps set of SNPs.
EGAS00000000034 | EGA
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