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TranscriptomicsThe PDZ-binding motif of SARS-CoV envelope protein is a determinant of viral pathogenesis
A recombinant SARS-CoV lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major virulence determinant in vivo. Elimination of SARS-CoV E protein PBM by using reverse genetics led to at...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-52920 | biostudies-arrayexpress
TranscriptomicsGene expression profile associated with the PDZ ligand-motif of HPV16-E6 oncoprotin in the skin of transgenic mice models
The K14E6 transgenic mice developskin hyperplasia,benign tumors and skin cancer. The tumor formation capacity diminishes when E6 lacks its PDZ ligand-motif. This study aims to compare the transciptional profiles of transgenic K14E6 mice with K14E6 Δ146-151 (lacking the PDZ domain) in order to explor...
ORGANISM(S): Mus musculus 
2010-07-27 | E-GEOD-22417 | biostudies-arrayexpress
ProteomicsMS analysis of photocrosslink adducts for the mapping of interaction sites of selective engineered PSD-95 PDZ domain ligands
Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhibitors is hindered by high similarity within the evolutionary...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD015366 | Pride
Engineered ligand/pdz domains/photocrosslinking/p-azidophenylalanine 
TranscriptomicsGene expression profile associated with the PDZ ligand-motif of HPV16-E6 oncoprotin in the skin of transgenic mice models
The K14E6 transgenic mice developskin hyperplasia,benign tumors and skin cancer. The tumor formation capacity diminishes when E6 lacks its PDZ ligand-motif. This study aims to compare the transciptional profiles of transgenic K14E6 mice with K14E6 Δ146-151 (lacking the PDZ domain) in order to explor...
ORGANISM(S): Mus musculus 
2010-07-27 | GSE22417 | GEO
GenomicsLPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization
LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization
PRJNA1152345 | ENA
ProteomicsQuantitative fragmentomics to map affinities of interactomes
~500,000 protein interactions have been identified in human but most binding affinities remain unknown, limiting quantitative investigation of interactome-function relationships. This gap can be filled by systematically measuring the affinities of minimal interacting protein fragments, the building ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027743 | Pride
Complexome Pdz Domain-motif interaction Interactome 
ProteomicsIdentification of host PDZ-based interactions with SARS-CoV-2 E protein in human monocytes
PDZ (Post-synaptic density, PSD-95)/ Disc large, Dlg/ Zonula occludens, ZO-1) proteins are central in the assembly of multiprotein signalling complexes that are formed in distinctive, specialized cell regions. In these complexes different signals are orchestrated and traduced into quick and efficien...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042620 | Pride
Viral targeting Sars-cov-2 Macrophage Innate immune response Syntenin Zo-2 Pdz Monocyte Il-16 Coronavirus Envelope e protein 
ProteomicsABCC4 protein interactions using IP-MS/MS
The ATP-binding cassette transporter ABCC4 regulates cAMP membrane microdomain formation after adenylate cyclase activation but how ABCC4 localizes to these membrane microdomains are still unclear. Herein we demonstrate that the assembly and spatiotemporal organization of ABCC4’s protein neighborhoo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD048010 | Pride
Abbc4 Ms/ms Pdz motif Ip 
UnknownEvolutionarily conserved bias of amino-acid usage refines the definition of PDZ-binding motif.
Not available
S-EPMC3138430 | biostudies-literature
UnknownThe amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF.
Not available
S-EPMC2728795 | biostudies-literature
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