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ProteomicsMolecular Basis of the mechanisms controlling MASTL - Proteomics analysis of MASTL substrate proteome and phosphorylation state
As part of our study on human MASTL (microtubule-associated serine/threonine kinase-like), we used mass spectrometry (MS)-based proteomics in the aim to unravel novel aspects about MASTL activation, regulation and potential substrates. Specifically, we performed a phosphoproteomics-based kinase assa...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD007991 | Pride
Human Lc-msms Mastl 
ProteomicsProteomics of late signaling responses decipher the roles of Cbl and Cbl-b in neuroblastoma cell differentiation
We applied quantitative mass spectrometry (MS)-based proteomics to study the roles of Cbl and Cbl-b in long-term signaling responses related to neurite outgrowth and differentiation of SH-SY5Y neuroblastoma cells. Using stable isotope labeling by amino acids in cell culture (SILAC) and tandem mass t...
ORGANISM(S): Homo sapiens (Human) 
2021-03-30 | PXD020389 | Pride
Human Lc-msms Neuroblastoma Cbl Cblb 
ProteomicsRepurposing of a known antipsychotic drug to target arthritogenic synovial fibroblasts
We applied quantitative mass spectrometry (MS)-based proteomics to investigate the phosphoproteome of hTNF-stimulated and Amisulpride-treated synovial fibroblasts (SFs), as part of a study aiming to find new potent orally-administered therapeutics to reverse the pathogenic expression signature of ar...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-11 | PXD035230 | Pride
Lc-msms Small molecule repurposing Tumor necrosis factor alpha Rheumatoid arthritis Synovial fibroblasts 
ProteomicsMolecular basis of Tousled-Like-Kinase 2 (TLK2) activation – LC-MS/MS-based analysis of TLK2 phosphorylation state
In this study on human Tousled-Like-Kinase 2 (TLK2) mass spectrometry-based analysis was applied as part of a molecular characterization of TLK2 in the aim to increase the understanding of the mode of activation of this protein. Specifically, different TLK2 constructs were analyzed to generate a “ph...
ORGANISM(S): Homo sapiens (Human) 
2018-10-23 | PXD007675 | Pride
Human Lc-msms Tlk2 
ProteomicsProteomics of NGF-TrkA signaling dynamics in neuroblastoma cells
We used quantitative mass spectrometry-based proteomics to unravel global nerve growth factor (NGF)-induced TrkA signaling dynamics at the interactome, phosphoproteome and proteome level. A tetracycline-inducible system for TrkA expression was generated in the human neuroblastoma cell line, SH-SY5Y....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080834 | MassIVE
MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
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