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MetabolomicsStructure of gut microbiota and characteristics of fecal metabolites in people living with HIV

Objective: The gut microbiome plays a pivotal role in human immunodeficiency virus (HIV) infection. However, the associated alterations in the gut microbiome-host interaction remain unclear. This study aims to investigate the gut microbiota and fecal metabolites in people living with HIV (PLWH).<...

2024-09-16 | MTBLS9264 | MetaboLights
TranscriptomicsBlood RNA sequencing in HIV-negative healthy volunteers and people living with HIV on effective, long-term anti-retroviral therapy
Immune activation in people living with HIV on anti-retroviral therapy is associated with increased risk of morbidity and mortality, but the underlying mechanisms are poorly understood. To identify whether perturbation of immunological pathways persist at systems level, we compared genome-wide whole...
ORGANISM(S): Homo sapiens 
2021-02-26 | E-MTAB-8891 | biostudies-arrayexpress
GenomicHIV-Resistant People with Hemophilia

Rare individuals are highly resistant to infection with human immunodeficiency virus (HIV). Studies of candidate genes resulted in the discovery of a 32bp deletion in the CC-chemokine receptor 5 gene (CCR5Δ32), which rendered this critical co-receptor for primary HIV infection to be non-func...

phs000445 | dbGaP
ProteomicsPersistent Type I Interferon Signaling in the Brain of People with HIV under ART with Cognitive Impairment
To examine the mechanisms that drive persistent neuroinflammation, we analyzed the proteome from 27 HIV-infected brains on antiretroviral therapy (ART) with different stages of HIV-associated neurocognitive disorders (HAND) by tandem mass tag quantitative proteomics. We observed that 73.3% of the up...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD042550 | Pride
Ifn Hiv-associated neurocognitive disorders (hand) Proteome 
ProteomicsBlood plasma from people living with HIV-1 or HIV-2
In this study we performed data-independet mass-spectrometry analysis of blood plasma collected from a cohort consisting of people living with HIV-1, people living with HIV-2, and HIV seronegative individuals. The data was used to infer signs of damage to a wide array of tissues and cell types.
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 2 Human immunodeficiency virus 1 
2024-02-16 | PXD045155 | Pride
Human Blood plasma Hiv-1 Hiv-2 
ProteomicsPeople with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells
CCR5 is the main HIV co-receptor. We aimed to (1) compare CCR5 expression on immune cells between people living with HIV (PLHIV) using combination antiretroviral therapy (cART) and HIV-uninfected controls, (2) relate CCR5 expression to viral reservoir size and (3) assess detereminants of CCR5 expres...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031628 | Pride
Hiv-1 Ccr5 Inflammation Persistent infection 
GenomicsSex Differences in Epigenetic Ageing for Older People Living with HIV
Sex Differences in Epigenetic Ageing for Older People Living with HIV
PRJNA1194131 | ENA
ProteomicsTargeted Plasma Proteomics Reveals a Central Role of Upregulated TNFRSF Proteins in HIV-associated Stroke: A Cross-sectional Discovery and Longitudinal Validation Study
This study investigated circulating proteomic signatures associated with stroke in people with HIV (PWH) using a nested case–control design. Plasma samples were collected from 135 HIV-positive individuals with stroke (HIV+/Stroke+), 135 HIV-positive stroke-free controls (HIV+/Stroke−), and 135 HIV-n...
ORGANISM(S): Homo sapiens (Human) 
2026-06-06 | PAD000032 | Pride
Stroke People with hiv Olink 
GenomicsCompromised Intestinal Barrier Resilience to Disruption in People with HIV [colon]
Compromised Intestinal Barrier Resilience to Disruption in People with HIV [colon]
PRJNA1200605 | ENA
GenomicsCompromised Intestinal Barrier Resilience to Disruption in People with HIV [ileum]
Compromised Intestinal Barrier Resilience to Disruption in People with HIV [ileum]
PRJNA1200619 | ENA
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