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TranscriptomicsComparison of effects of Iodine-deficiency and perchlorate on thyroid
Perchlorate, which is a ubiquitous and persistent ion, competitively interferes with iodide accumulation in the thyroid, causing iodine deficiency, which may result in reduced thyroid hormone synthesis and secretion. Human studies suggest that perchlorate presents very little risk in healthy individ...
ORGANISM(S): Rattus norvegicus 
2010-11-04 | E-GEOD-25144 | biostudies-arrayexpress
ProteomicsSurviving Martian Brines: Proteomic Analysis of Escherichia coli’s Adaptation to Perchlorate Stress
Brines, potentially formed by the deliquescence and freezing point depression of highly hygroscopic salts, such as perchlorates (ClO4-), may allow for the spatial and temporal stability of liquid water on present-day Mars. It is therefore of great interest to explore the microbial habitability of Ma...
ORGANISM(S): Escherichia coli 
2025-01-21 | PXD055273 | Pride
Mars Adaptation Astrobiology Brines Perchlorate Habitability 
ProteomicsSurviving Mars: The role of black fungus Rhinocladiella similis in understanding life in perchlorate-rich environments
The study of the survival of terrestrial microorganisms in Martian conditions, especially in the presence of perchlorates, offers crucial insights for astrobiology. This research investigates the resilience of the extremophilic black fungus Rhinocladiella similis to the exposure to magnesium perchlo...
ORGANISM(S): Rhinocladiella similis 
2025-05-26 | PXD050600 | Pride
Omics. Space exploration Uv-c radiation Rhinocladiela similis Extremophiles Perchlorate brines 
ProteomicsPerchlorate-Specific Proteomic Stress Responses of Debaryomyces hansenii Could Enable Microbial Survival in Martian Brines
If life exists on Mars, it would face several challenges including the presence of perchlorates, which destabilize biomacromolecules by inducing chaotropic stress. However, little is known about perchlorate toxicity for microorganism on the cellular level. Here we present a proteomic investigation o...
ORGANISM(S): Debaryomyces hansenii 
2023-06-06 | PXD033237 | Pride
Debaryomyces hansenii Astrobiology Mars Martian brines Perchlorate Stress response 
GenomicsTranscriptomic fingerprints of C. elegans exposed to sodium perchlorate.
Transcriptomic fingerprints of C. elegans exposed to sodium perchlorate.
PRJNA629333 | ENA
ProteomicsAeropyrum pernix K1 LC-MSMS - Perchlorate and chlorate reduction by the Crenarchaeon Aeropyrum pernix and two thermophilic Firmicutes
The study investigated the ability of selected (hyper-)thermophilic prokaryotes to grow anaerobically by the reduction of perchlorate and chlorate. Physiological, genomic and proteome analyses suggest that the Crenarchaeon Aeropyrum pernix reduces (per)chlorate with a periplasmic enzyme related to n...
ORGANISM(S): Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 
2017-06-02 | PXD001683 | Pride
Lc-msms Crenarchaeon Aeropyrum Hyperthermophile 
ProteomicsProteomic Insights into Psychrophile Growth in Perchlorate-Amended Subzero Conditions: Implications for Martian Life Detection
Forty-five Colwellia psychrerythraea 34H (Cp34H) samples were individually prepared for mass spectrometry proteomics to identify proteomic effects of perchlorate oxy-ions and putative perchlorate-tolerant biosignatures. Cultures of Cp34H were grown in half-strength 2216 medium at -1°C to late log ph...
ORGANISM(S): Colwellia psychrerythraea 34H 
2025-02-14 | PXD050418 | Pride
Perchlorate Colwellia psychrerythraea 34h 
TranscriptomicsTranscriptomic fingerprints of C. elegans exposed to sodium perchlorate.
The excessive perchlorate utilization as an oxidizer in rocket propellants and blasting agents had led to the contamination of surface and ground waters. This chemical is known to compete with iodine for binding to the thyroid membrane receptors potentially causing hypothyroidism and fetal retardati...
ORGANISM(S): Caenorhabditis elegans 
2020-04-30 | GSE149596 | GEO
GenomicsEffects of Potassium Perchlorate on Developing Medaka Primordial Germ Cells
Effects of Potassium Perchlorate on Developing Medaka Primordial Germ Cells
PRJNA739694 | ENA
TranscriptomicsComparison of effects of Iodine-deficiency and perchlorate on thyroid
Perchlorate, which is a ubiquitous and persistent ion, competitively interferes with iodide accumulation in the thyroid, causing iodine deficiency, which may result in reduced thyroid hormone synthesis and secretion. Human studies suggest that perchlorate presents very little risk in healthy individ...
ORGANISM(S): Rattus norvegicus 
2010-11-04 | GSE25144 | GEO
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