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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownA Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data.
Not available
S-EPMC8518716 | biostudies-literature
UnknownProdromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology.
Not available
S-EPMC7744294 | biostudies-literature
UnknownRetinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection.
Not available
S-EPMC4339396 | biostudies-literature
ProteomicsEnhanced interactome capture (eRIC) of steady-state and arsenite stressed HuH7 cell cytoplasmic and nuclear fractions
HuH7 cells were grown under steady-state conditions or exposed 100 µM Na-arsenite for 1h. Subsequently, the cells were irradiated or not with 253 nm UV light (150 mJ/cm^2), processed to nuclear and cytoplasmic fractions, and subjected to eRIC for determining the nuclear and cytoplasmic RNA-binding ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-06 | PXD016735 | Pride
Human Cell culture Arsenite 
ProteomicsGlobal assessment of protein-protein crosslinking in ex vivo eRIC samples
Male mice on a homogenous C57BL6/J genetic background were sacrificed at 11 to 13 weeks of age by cervical dislocation. Kidneys were immediately harvested, flash frozen in liquid nitrogen and stored at -80°C until use. Animal handling was in accordance with guidelines approved by the European Molecu...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-02 | PXD038100 | Pride
Rna interactome capture. Rbp Ric Eric Rna binding protein Rbpome 
ProteomicsNon-poly(A) RNA Interactome Capture (RIC) of mouse brain, kidney and liver
Male mice on a homogenous C57BL6/J genetic background were sacrificed at 11 to 13 weeks of age by cervical dislocation. Brain, kidneys and liver were immediately harvested, flash frozen in liquid nitrogen and stored at -80°C until use. Animal handling was in accordance with guidelines approved by th...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-02 | PXD038076 | Pride
Rna interactome capture. Rbp Ric Eric Rna binding protein Rbpome 
ProteomicsNon-poly(A) RNA Interactome capture (RIC) of mouse liver
Male mice on a homogenous C57BL6/J genetic background were sacrificed at 11 to 13 weeks of age by cervical dislocation. Liver were immediately harvested, flash frozen in liquid nitrogen and stored at -80°C until use. Animal handling was in accordance with guidelines approved by the European Molecula...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-02 | PXD038099 | Pride
Rna interactome capture. Rbp Ric Eric Rna binding protein Rbpome 
ProteomicsEnhanced RNA Interactome capture (eRIC) and RNA Interactome capture (RIC) of Jurkat cells (DSMZ, ACC-282) exposed to 0.5mM DMOG or vehicle (DMSO) for 6 hours.
1.0 – 1.3 x 10e8 proliferating Jurkat cells at a density of about 1-1.5 x 10e6 cells/mL were employed per sample. Cells were incubated with 0.5mM DMOG (Cayman Chemical Company, 71210) or an equivalent volume of Dimethyl Sulfoxide (DMSO) (vehicle, Merck 1.02950.0500). The DMSO concentration in the...
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD010942 | Pride
Dmog Ric Eric N6-methyladenosine Epitranscriptome M6a Rna interactome Rbps Rbpome Rna-binding proteins Dimethyloxalylglycine 
ProteomicsEnhanced RNA Interactome capture (eRIC) and RNA Interactome capture (RIC) of Jurkat cells (DSMZ, ACC-282).
1.0 – 1.3 x 10e8 proliferating Jurkat cells at a density of about 1-1.5 x 10e6 cells/mL were employed per sample. Cells were irradiated or not with 254 nm UV light and subjected to eRIC or RIC to determine the RNA-bound proteome. Data correspond to two biologically independent experiments.
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD010941 | Pride
Ric Eric Rna interactome Rbps Rbpome Rna-binding proteins 
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