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Post expression from the host cell, a bio-therapeutic will be subjected to several downstream processing steps prior to final formulation. Analysis of the product under various buffer conditions at each stage is desirable to show that the integrity of the sample is maintained and to monitor any pote...
ORGANISM(S): Homo sapiens (Human) 
2024-07-12 | PXD051563 | Pride
relied on two-dimensional (2D) static cultures which neglect the dynamic,three-dimensional (3D) nature of the biophysical tumour microenvironment (TME), especially the role and impact of interstitial fluid flow (IFF). To address this, we undertook a transcriptome-wide analysis of the impact of IFF-l...
ORGANISM(S): Homo sapiens 
Glioblastoma patient samples were microdissected into ~20mg pieces and put onto a novel perfusion device, within an hour of resection. Samples were left for 8 days, at a flow rate of 3ul/min, with a media change at day 4. Treatment was with 1uM GSK3368715. Please refer to Barry et al. Lab-on-chip 20...
ORGANISM(S): Homo sapiens 
2023-05-09 | GSE226721 | GEO
Effect of GSK3368715 on GBM patient samples, kept in a novel perfusion device for 8-days
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