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TranscriptomicsTranscription profiling of mouse liver in conditional knockouts of the tumor suppressor gene Apc identifies Wnt/bet-catenin signaling activation in hepatocytes
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Conditional Knockout mouse model for the tumor suppressor gene Ap, Apc 2lox. The disruption of the Apc gene is realized by injection of an adenovirus encoding the Cre recom...
ORGANISM(S): Mus musculus 
2006-03-13 | E-TABM-81 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type and tumor suppressor Apc knock-out mice
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). This work aims to demonstrate a key role for the Wnt/beta-catenin pathway in liver embryonic growth and in controlling the fate of hepatoblasts, preventing them to differen...
ORGANISM(S): Mus musculus 
2007-08-07 | E-TABM-295 | biostudies-arrayexpress
ProteomicsLkb1 suppresses amino acid-driven gluconeogenesis in the liver
Excessive glucose production in the liver is a key factor in the hyperglycemia observed in diabetes mellitus type 2. It is generally agreed to result from an increase in hepatic gluconeogenesis. Considerable attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes, b...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD019757 | Pride
Gluconeogenesis Phosphoproteome Sarcopenia Liver Cachexia Q-exactive Label-free quantification Amino acids Lkb1 Orbitrap fusion 
ProteomicsProteome analysis of formalin-fixed paraffin-embedded colorectal adenomas reveals the heterogeneous nature of Traditional Serrated Adenoma compared to the other colorectal adenomas
Traditional serrated adenoma (TSA) remains the least understood of all the colorectal adenomas although these lesions have been associated with a significant cancer risk- twice that of the conventional adenoma (CAD) and of the sessile serrated adenoma (SSA/P). This study was performed to investigat...
ORGANISM(S): Homo sapiens (Human) 
2020-01-21 | PXD014511 | Pride
Colon adenoma  label free quantification  proteomics  formalin-fixed paraffin-embedded  ffpe  sessile serrated adenoma  traditional serrated adenoma  orbitrap fusion 
ProteomicsLKB1 is a suppressor of amino acid-driven gluconeogenesis in the liver
Excessive hepatic glucose production is a major contributor to the hyperglycemia observed in Type 2 diabetes mellitus. It is widely accepted that it is due to an increase in hepatic gluconeogenesis. While much attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes,...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD013478 | Pride
Gluconeogenesis Maxquant Mus musculus Sarcopenia Liver Q-exactive Label-free Amino acids Lkb1 Insulin 
ProteomicsLkb1 suppresses amino acid-driven gluconeogenesis in the liver
Excessive glucose production in the liver is a key factor in the hyperglycemia observed in diabetes mellitus type 2. It is generally agreed to result from an increase in hepatic gluconeogenesis. Considerable attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes, b...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD019755 | Pride
Gluconeogenesis Phosphoproteome Sarcopenia Liver Cachexia Q-exactive Label-free quantification Amino acids Lkb1 Orbitrap fusion Refed mice 
UnknownThe tumor suppressorApccontrols planar cell polarities central to gut homeostasis
Not available
S-JCBD-201204086 | bioimages
TranscriptomicsImpact of bariatric surgery on RNA-seq gene expression profiles of adipose tissue in humans
Bariatric surgery is the most effective therapy of severe human obesity. It is associated with improvements in metabolic and non metabolic co-morbidities which are thought to be mediated by a decrease of adipose tissue inflammation. However, the molecular mechanisms behind these beneficial effects a...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-65540 | biostudies-arrayexpress
TranscriptomicsImpact of bariatric surgery on RNA-seq gene expression profiles of peripheral monocytes in humans
Genome-wide expression profiles in peripheral monocytes (PM) from 19 obese women before and 3 months after bariatric surgery using the RNA-seq technology. This dataset is linked to the dataset GSE65540 providing expression profiles in subcutaneous adipose tissue (SAT) in the same population. Due to ...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-66306 | biostudies-arrayexpress
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