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TranscriptomicsLong noncoding RNA expression during human B-cell development
Long noncoding RNAs (lncRNAs) have emerged as important regulators of diverse cellular processes, but their roles in the developing immune system are poorly understood. In this study, we analysed lncRNA expression during human B-cell development by array-based expression profiling of eleven distinct...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-69033 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles of CD21low B cells in Common Variable Immunodeficiency
The homeostasis of circulating B cell subsets in the peripheral blood of healthy adults is well regulated, but in disease it can be severely disturbed. Thus, a subgroup of patients with common variable immunodeficiency (CVID) presents with an extraordinary expansion of an unusual B cell population c...
ORGANISM(S): Homo sapiens 
2009-07-30 | E-GEOD-17269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouseWT vs CD137L-/- GC B cells
WT and CD137L-/- mice of 8-12 weeks old were immunized intra-peritoneally with 50 µg chicken gamma- globulin conjugated to 4-hydroxy-3-nitrophenylacetyl (NP-CG) in alum or infected intranasally with 25 hemagglutinin units of influenza virus strain A/NT/60/68 in 50 µl HBSS. Nine days after immuniza...
ORGANISM(S): Mus musculus 
2009-07-24 | E-NCMF-29 | biostudies-arrayexpress
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mature, naive B cells to investigate how the PTPN22 autoimmune susceptibility gene affects the removal of human developing autoreactive B cells.
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene segregates with most autoimmune diseases; its risk allele encodes overactive PTPN22 phosphatases that alter B cell receptor (BCR) signaling potentially involved in the regulation of central B cell tolerance. To assess whether PTPN22 ris...
ORGANISM(S): Homo sapiens 
2010-10-16 | E-GEOD-24736 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of genetically and clinically distinct subgroups of human B-cell chronic lymphocytic leukemia patients
We used high density oligonucleotide arrays to identify molecular correlates of genetically and clinically distinct subgroups of B-cell chronic lymphocytic leukemia (B-CLL). Gene expression profiling was used to profile the five most frequent genomic aberrations, namely deletions affecting chromosom...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2466 | biostudies-arrayexpress
TranscriptomicsA Phase Two Randomised Controlled Trial of Belimumab in Kidney Transplant Recipients Demonstrates Comparable Safety, a Reduction in De Novo Antibody Production and an Increase in Regulatory B Cells.
There is an urgent unmet need in solid organ transplantation for immunotherapeutic strategies that target B cells and plasma cells, ideally without increasing infectious complications. We conducted a phase 2 double-blind randomised placebo-controlled trial to assess the safety and potential efficacy...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5906 | biostudies-arrayexpress
ProteomicsSite-specific profiling of structure and function of IgM B cell receptor glycans
Although N-linked glycans play pivotal roles in the regulation of antibody effector functions, little is known about the composition and functional impact of glycans expressed by human B cell receptors (BCRs), likely due to technical challenges. Here, we describe the site-specific glycosylation prof...
ORGANISM(S): Homo sapiens (Human) 
2025-12-09 | PXD062559 | Pride
Igm Primary naïve and memory b cells N-linked glycosylation Human b cell receptors 
TranscriptomicsTranscription profiling by array of a time series of wild type or Mef2c-deficient mouse B-cells following antigen-receptor stimulation
Control or Mef2c-deficient (cKO) B cells were treated with 5ug/ml anti-IgM for 0, 6, 12, 24, or 48 hours before harvesting RNA for analysis.
ORGANISM(S): Mus musculus 
2008-05-01 | E-MEXP-1511 | biostudies-arrayexpress
GenomicsGenetic and Functional Drivers of Diffuse Large B Cell Lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common hematologic malignancy and is characterized by a striking degree of heterogeneity. We enrolled a total of 1001 DLBCL patients and comprehensively defined the landscape of genetic mutations, copy number alterations and expression through whole-...
EGAS00001002606 | EGA
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