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ProteomicsProteomics analysis of involvemnt of miRNA 465 in hybrid mouse sterility, 12 days
One of the reproductive isolation mechanisms that restricts gene exchange and make speciation irreversible is sterility of inter(sub)specific hybrids. In the Prdm9-driven sterility of Mus m. musculus x Mus m. domesticus hybrids a Prdm9-interacting hybrid sterility gene was mapped in the X-linked Hst...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD062935 | Pride
Mir465 Hybrid sterility Inbred mouse strain 
ProteomicsProteomics analysis of involvemnt of miRNA 465 in hybrid mouse sterility, 18 days
One of the reproductive isolation mechanisms that restricts gene exchange and make speciation irreversible is sterility of inter(sub)specific hybrids. In the Prdm9-driven sterility of Mus m. musculus x Mus m. domesticus hybrids a Prdm9-interacting hybrid sterility gene was mapped in the X-linked Hst...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD062724 | Pride
Sterility Mir465 Inbred mouse strain 
TranscriptomicsRNA-Seq of human lung cancer cell line A549 co-cultivated with cancer-associated fibroblasts from brain metastases
In this study, we investigate the differences in the A549 human lung adenocarcinoma cell line when cultured independently versus in co-culture with cancer-associated fibroblasts (CAFs). After cultivation, tumor cells were isolated by cell sorting to ensure high purity (sorting purity >98%, and often...
ORGANISM(S): Homo sapiens 
2026-07-28 | E-MTAB-15451 | biostudies-arrayexpress
TranscriptomicsTranscriptomics analysis of involvement of miRNA 465 in hybrid mouse sterility
In the Prdm9-driven sterility of Mus m. musculus x Mus m. domesticus hybrids a Prdm9-interacting hybrid sterility gene was mapped in the X-linked Hstx2 locus. Here we show that the Mir465 microRNA gene cluster is the predicted Hstx2 hybrid sterility factor involved in Prdm9 interaction.
ORGANISM(S): Mus musculus 
2025-12-16 | E-MTAB-15076 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling by RNA-seq of fibroblast isolated from a brain pathological tissue
In this study, we address the difference in adult fibroblasts developmentally originating from different germ layers. Closer, we focussed on HOX gene expression and the potential influence of physiological and pathological conditions in postnatal life. Here we specifically focused on fibroblasts fr...
ORGANISM(S): Homo sapiens 
2025-07-15 | E-MTAB-13242 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of fibroblasts influenced by exosomes derived from melanoma cell line G-361
In this in-vitro study, we demonstrate the different effects of exosomes produced by melanoma cells on the functional properties of normal dermal fibroblasts and fibroblasts prepared from skin metastasis of CMM. Both normal and cancer-associated fibroblast were prepared by a)DMEM with 10% EDS (contr...
ORGANISM(S): Homo sapiens 
2022-12-31 | E-MTAB-10278 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling by RNA-seq of fibroblast isolated from a skin of a human face and a human forearm
In this study, we address the difference in adult fibroblasts developmentally originating from different germ layers. Closer, we focussed on HOX gene expression and the potential influence of physiological and pathological conditions in postnatal life. Here we specifically focused on fibroblasts fro...
ORGANISM(S): Homo sapiens 
2025-07-15 | E-MTAB-13243 | biostudies-arrayexpress
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