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MetabolomicsPerfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity
Not available
ORGANISM(S): Mus musculus 
ST001525 | MetabolomicsWorkbench
GenomicsPhotoperiod perturbations impact perfluorohexane sulfonate (PFHxS) induced developmental toxicity [PFHxS-5day]
Photoperiod perturbations impact perfluorohexane sulfonate (PFHxS) induced developmental toxicity [PFHxS-5day]
PRJNA1365889 | ENA
TranscriptomicsPhotoperiod perturbations impact perfluorohexane sulfonate (PFHxS) induced developmental toxicity [PFHxS-5day]
Perfluorohexane sulfonate (PFHxS) is a persistent perfluoroalkyl substance with increasing scrutiny due to its widespread occurrence and potential for developmental neurotoxicity. In this study, we investigated how photoperiod - a critical regulator of circadian physiology- modulates PFHxS toxicity ...
ORGANISM(S): Danio rerio 
2026-07-01 | GSE310402 | GEO
TranscriptomicsPFOS and PFHxS decrease lipoprotein production
The effect of perfluoroalkyl sulfonates on lipoprotein metabolism was investigated in APOE*3-Leiden.CETP mice with a humanized lipoprotein profile. Perfluorohexane sulfonate and perfluorooctane sulfonate markedly reduced both plasma TG and TC by decreasing nonHDL-C and HDL-C accompanied by a reducti...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22940 | biostudies-arrayexpress
TranscriptomicsChicken embryonic cerebral cortex exposed to two doses of PFHxS.
In a recent egg injection study, we showed that in ovo exposure to perfluorohexane sulfonate (PFHxS) affects the pipping success of developing chicken (Gallus gallus domesticus) embryos. We also found evidence of thyroid hormone (TH) pathway interference at multiple levels of biological organization...
ORGANISM(S): Gallus gallus 
2012-04-17 | E-GEOD-37339 | biostudies-arrayexpress
ProteomicsLow dose perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) augment hepatic steatosis and shift the sera lipidome in a high fat high carbohydrate diet.
Non-alcoholic fatty liver disease (NAFLD) is most prevalent form of liver disease, affecting over 30% of Americans. Perfluoroalkyl substances (PFAS) represent a family of environmental toxicants that have infiltrated the living world. This study explores diet-PFAS interactions and their potential ro...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-15 | PXD015976 | Pride
Pfos High fat diet Hepatotoxicity Fatty liver disease Pfhxs Nafld 
TranscriptomicsChicken embryonic cerebral cortex exposed to two doses of PFHxS.
In a recent egg injection study, we showed that in ovo exposure to perfluorohexane sulfonate (PFHxS) affects the pipping success of developing chicken (Gallus gallus domesticus) embryos. We also found evidence of thyroid hormone (TH) pathway interference at multiple levels of biological organization...
ORGANISM(S): Gallus gallus 
2012-04-18 | GSE37339 | GEO
UnknownPFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease.
Not available
S-EPMC10815161 | biostudies-literature
ProteomicsExposure to a PFOA, PFOS and PFHxS mixture during gestation and lactation alters the liver proteome in offspring of CD-1 mice
PFAS are persistent man-made chemicals considered to be emerging pollutants, with PFOA, PFOS, and PFHxS having associations with liver toxicity and steatosis. PFOA, PFOS, and PFHxS can undergo placental/lactational transfer, however, little is known about the impact of PFAS mixtures during the devel...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-09 | PXD052106 | Pride
Pfoa Cd-1 mouse Pfos Maternal exposure Perinatal Proteome Hepatotoxicity Liver Pfas mixture Pfhxs 
Genomics
PFHxS RNA sequencing
PRJNA1345223 | ENA
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