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MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
ProteomicsBacteria conjugate ubiquitin-like proteins to interfere with phage assembly
Two immunoprecipitation datasets of phage SECphi27 and SECphi4 modified by the Bil defense system. For both phages, control samples with a mutated Bil defense system were run.
ORGANISM(S): Escherichia phage SECphi4 Escherichia phage SECphi27 Escherichia coli 
2024-07-18 | PXD044622 | Pride
Immunology Isg15 Bacteria Defense Phage 
ProteomicsStructure and mechanism of the Zorya anti-phage defense system
Zorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been discovered, each containing predicted membrane-embedded ZorAB complexes paired with soluble subunits that differ among Zorya subtypes, no...
ORGANISM(S): Escherichia coli 
2025-01-24 | PXD047450 | Pride
Phage Phage defense system Bacterial immune system Zorya Ion-driven motor 
ProteomicsA Phage Protein Kinase Subverts Bacterial Defense Systems through Hyperpromiscuous Phosphorylation
Bacteria and bacteriophages are in a constant arms race to develop bacterial defense and phage counter-defense systems. The prevailing view so far has been that phage counter-defense systems target specific bacterial defense systems. Here, we uncover a mechanism by which the T7 bacteriophage broadly...
ORGANISM(S): Escherichia coli 
2026-06-17 | PXD058408 | Pride
Phosphoproteomics Phage Defense systems 
ProteomicsEffects of ShosTA system on E.coli
To elucidate that ShosTA exerts an anti-phage function, we further explored the interacting proteins of ShosA. IP-MS/MS analysis reveals in vivo interactions between ShosA and some recombination-associated proteins. FLAG-tagged ShosA in the context of the full ShosTA system or FLAG-tag alone are use...
ORGANISM(S): Escherichia Coli 
2024-09-25 | PXD056215 |
GenomicsStructural mechanism of the Retron-Eco7 anti-phage defense system
Structural mechanism of the Retron-Eco7 anti-phage defense system
PRJNA1244356 | ENA
GenomicsViral SSB-bound ssDNA activates the bacterial anti-phage defense system DARNA
Viral SSB-bound ssDNA activates the bacterial anti-phage defense system DARNA
PRJNA1439913 | ENA
GenomicsStructure-functional characterization of Lactococcus AbiA phage defense system
Structure-functional characterization of Lactococcus AbiA phage defense system
PRJEB71919 | ENA
ProteomicsRetron Eco2 breaks tRNAs for anti-phage defense
Retrons mediate bacterial anti-phage defense by reverse transcribing non-coding RNA into multicopy single-stranded DNA (msDNA). Our study reveals the unique trimeric nucleoprotein structure of Eco2, which solely relies on a single protein for defense, unlike most other retrons. This structure suppor...
ORGANISM(S): Escherichia coli 
2026-02-03 | PXD060313 | Pride
Retron Cryo-em Hdx-ms Anti-phage defense 
GenomicsStructural mechanism of the Retron-Eco7 anti-phage defense system
Retrons are prokaryotic genetic elements involved in anti-phage defense and consist of a non-coding RNA, a reverse transcriptase (RT), and various effector proteins. Retron-Eco7 (previously known as Retron-Ec78) from Escherichia coli encodes two effector proteins (a PtuA ATPase and a PtuB nuclease) ...
ORGANISM(S): Escherichia coli str. K-12 substr. DH10B 
2025-10-23 | GSE293394 | GEO
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