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ProteomicsLung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
Resident tissue macrophages (RTMs) are organ-specialized phagocytes responsible for the maintenance and protection of residing tissue. It is well established that tissue diversity is reflected by the heterogeneity of RTMs origin and phenotype. However, much less is known about tissue-specific phagoc...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-18 | PXD033010 | Pride
Phagocytosis Proteomics Cathepsins Resident tissue macrophages Phagosome maturation 
ProteomicsSpatiotemporal changes of the phagosomal proteome in dendritic cells in response to LPS stimulation
Dendritic cells (DCs) are professional phagocytes that use innate sensing and phagocytosis to internalize and degrade self as well as foreign material, such as pathogenic bacteria, within phagosomes. These intracellular compartments are equipped to generate antigenic peptides that serve as source fo...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-28 | PXD012155 | Pride
Phagosomes Mass spectrometry Label-free quantification Denditric cells 
UnknownSpatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation.
Not available
S-EPMC6495253 | biostudies-literature
ProteomicsComplement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.
Critical illness is characterised by organ failure, dysregulated immune activation and frequent secondary infections. Unbridled complement activation in these patients exposes immune cells to high levels of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of key immune cells, in partic...
ORGANISM(S): Homo sapiens (Human) 
2020-08-06 | PXD017092 | Pride
Critical care Neutrophils Staphylococcus aureus Complement system proteins Phosphoproteome 
UnknownThe dynamic phagosomal proteome and the contribution of the endoplasmic reticulum.
Not available
S-EPMC2141809 | biostudies-literature
ProteomicsPacific oyster phagosome LC-MSMS
Phagosomes are task-force organelles of innate immune systems responsible for the recognition, processing, and ultimately destruction of invading microorganisms. Among invertebrate and vertebrate species, evolutionary diversity and continuity abound in the protein machinery executing this coordinate...
ORGANISM(S): Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 
2020-04-27 | PXD015810 | Pride
Innate immunity Actin remodeling Oyster Phagosome 
ProteomicsPhagoID: Quantitative in situ proximity labeling defines the proteomes of bead- and microbe-containing phagosome lumina across species, maturation, and immune activation
The phagosome is an immune organelle that integrates signals from diverse cargos to drive pathogen killing, tissue homeostasis, and antigen presentation. How this compartment coordinates such diverse functions remains incompletely understood. A comprehensive view of phagosomal composition across cel...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-10-02 | PXD055598 | Pride
Apex2 Turboid Proximity labeling Phagosome proteome Phagosomal proteome Hrp Phagosome lumen Phagosomal lumen Phagosome 
UnknownHemocyte phagosomal proteome is dynamically shaped by cytoskeleton remodeling and interorganellar communication with endoplasmic reticulum during phagocytosis in a marine invertebrate, Crassostrea gigas.
Not available
S-EPMC7171069 | biostudies-literature
UnknownProteomic analysis of Atg8-dependent recruitment of phagosomal proteins in the enteric protozoan parasite Entamoeba histolytica.
Not available
S-EPMC9575557 | biostudies-literature
ProteomicsComaprison of the phagosome proteome of bone marrow-derived macrophages and RAW264.7
Macrophages are important immune cells operating at the forefront of innate immunity by taking up foreign particles and microbes through phagocytosis. The RAW 264.7 cell line is commonly used for experiments in the macrophage and phagocytosis field. However, little is known how its functions compare...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-08 | MSV000084938 | MassIVE
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