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ProteomicsThe E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to infection
Phagocytosis is an essential process for the microbicidal function of professional phagocytes, in which phagosome maturation plays a critical role. Macrophage activation by interferons (IFN) increases their microbicidal activity, but delays phagosomal maturation. Here, we investigated the role of ub...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-20 | PXD026843 | Pride
Macrophage Phagosome Rnf115 Ubiquitin E3-ligase 
ProteomicsPacific oyster phagosome LC-MSMS
Phagosomes are task-force organelles of innate immune systems responsible for the recognition, processing, and ultimately destruction of invading microorganisms. Among invertebrate and vertebrate species, evolutionary diversity and continuity abound in the protein machinery executing this coordinate...
ORGANISM(S): Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 
2020-04-27 | PXD015810 | Pride
Innate immunity Actin remodeling Oyster Phagosome 
ProteomicsTemporal and ligand effects on phagosome maturation
Systems biology analysis of temporally-resolved phagosome proteomes following uptake via key phagocytic receptors Macrophages operate at the forefront of innate immunity, and their discrimination of pathogenic versus “self” particles is critical for a number of responses including efficient pathogen...
ORGANISM(S): Mus musculus (Mouse) 
2015-09-10 | PXD000772 | Pride
Phagocytosis Macrophage Proteomics Mtraq Phagosome 
GenomicsA unique Mitochondrial Quality Control (MQC) mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis
A unique Mitochondrial Quality Control (MQC) mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis
PRJNA896529 | ENA
UnknownAutophagy proteins are not universally required for phagosome maturation.
Not available
S-EPMC5082775 | biostudies-literature
UnknownA Drosophila model to image phagosome maturation.
Not available
S-EPMC3972680 | biostudies-literature
ProteomicsTPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria
Tumor Progression Locus 2 (TPL-2) kinase mediates Toll-like Receptor (TLR) activation of ERK1/2 and p38 MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase-independent regulatory function for TPL-2 in phagosome maturation,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-24 | PXD020247 | Pride
Macrophage Bacteria Tpl-2 V-atpase Staphylococcus aureus Dmxl1 Phagosome 
UnknownEeukaryotic-like Sppsk1 from Vibrio splendidus AJ01 mediates phagosome escape via inhibiting phagosome acidification and maturation.
Not available
S-EPMC11846826 | biostudies-literature
ProteomicsTPL-2 kinase induces phagosome acidification to promote macrophage killing of Staphylococcus aureus
Tumor Progression Locus 2 (TPL-2) kinase mediates Toll-like Receptor (TLR) activation of ERK1/2 and p38-alpha MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase-independent regulatory function for TPL-2 in phagosome matur...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD020401 | Pride
Macrophage  phagosome Staphylococcus aureus  tpl-2  v-atpase 
UnknownSec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites.
Not available
S-EPMC10550925 | biostudies-literature
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