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ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080766 | MassIVE
ProteomicsHuman ccRCC cell line 786-O with PHD3 knockdown LC-MS/MS
Appreciating the pseudohypoxic signalling in ccRCC cells we decided to look into the effects of an established hypoxia-related enzyme, namely PHD3, in ccRCC development. Interestingly, these cells express PHD3 in unusually high amounts, a phenomena yet unexplained. We were interested in determining ...
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD005453 | Pride
Human Cancer Ccrcc Phd3 
TranscriptomicsProlyl hydroxylase PHD3 is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Neutrophils were isolated form peripheral blood of wildtype and Phd3 null mice, cultured for 4 hours in hypoxia (3% O2) and micro array analysis performed The aim of the present study is to identify the mechanism by which phd3 is required for the hypoxia mediated survival of neutrophils Murine perip...
ORGANISM(S): Mus musculus 
2011-02-08 | E-GEOD-26023 | biostudies-arrayexpress
ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo sapiens (Human) 
2016-03-30 | PXD001085 | Pride
Mapk6 Dmog Ripk4 Erk3 Hypoxia Hydroxylases 
ProteomicsCross-linking MS analysis of HIV-2 Vpx-PHD3 protein interaction
This dataset presents chemical crosslinking mass spectrometry (CL-MS) analysis of protein-protein interactions between HIV-2 Vpx and PHD3. The experimental data includes MS spectra obtained from protein complexes comprising recombinant Vpx and PHD3 crosslinked using DSBU under physiological conditio...
ORGANISM(S): Human Immunodeficiency Virus 2 
2025-04-03 | PXD059241 | JPOST Repository
TranscriptomicsProlyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
On molecular level cells sense changes in oxygen availability through the prolyl-4-hydroxylase domain enzymes (PHDs), which regulate the protein stability of the α-subunit of the transcription factor hypoxia inducible factor (HIF). Especially PHD3 has been additionally associated with apoptotic cell...
ORGANISM(S): Mus musculus 
2014-12-31 | GSE55693 | GEO
ProteomicsPHD3-mediated HIV-2 Vpx peptide hydroxylation
This dataset contains comparative mass spectrometry analysis investigating proline hydroxylation of synthetic HIV-2 Vpx peptides under two conditions: with and without PHD3 enzyme treatment. The analysis was performed using a high-resolution mass spectrometer coupled to a nano-LC system. The dataset...
ORGANISM(S): Human Immunodeficiency Virus 2 
2025-04-03 | PXD059242 | JPOST Repository
TranscriptomicsProlyl hydroxylase PHD3 is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Neutrophils were isolated form peripheral blood of wildtype and Phd3 null mice, cultured for 4 hours in hypoxia (3% O2) and micro array analysis performed The aim of the present study is to identify the mechanism by which phd3 is required for the hypoxia mediated survival of neutrophils
ORGANISM(S): Mus musculus 
2011-02-08 | GSE26023 | GEO
UnknownPHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway.
Not available
S-EPMC10679873 | biostudies-literature
UnknownPHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer.
Not available
S-EPMC2990580 | biostudies-literature
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