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UnknownTargeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation.
Not available
S-EPMC6748371 | biostudies-literature
GenomicsDorsal dependent CBP binding on a genome wide scale
We find a high concordance between the binding of the Drosophila transcription factor Dorsal and the co-activator CBP during early embryogenesis. This relationship was furter examined by comparing CBP distribution in Drosophila embryos derived from wt and mutant flies lacking intranuclear Dorsal (gd...
ORGANISM(S): Drosophila melanogaster 
2012-06-28 | E-GEOD-34221 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human BeWo trophoblasts stimulated with Coxiella burnetii, the agent of Q fever
The transcriptional response of BeWo cells stimulated with C. burnetii was analyzed using microarrays covering the whole human genome.
ORGANISM(S): Homo sapiens 
2011-06-01 | E-MEXP-2800 | biostudies-arrayexpress
ProteomicsProteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma
We have shown previously that rapamycin, the canonical inhibitor of the mechanistic target of rapamycin (mTOR) complex 1, markedly inhibits the growth of focal lesions in the resistant hepatocyte (Solt-Farber) model of hepatocellular carcinoma (HCC) in the rat. In the present study, we characterized...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005845 | Pride
Proteomics Liver Hepatocellular carcinoma Laser capture microscopy Pre-neoplasia 
UnknownPatterns and predictors of failure following tri-modality therapy for locally advanced esophageal cancer.
Not available
S-EPMC6854665 | biostudies-literature
TranscriptomicsIron regulation in P. syringae DC3000
DC3000 cultures were grown under highly controlled conditions and after the addition of iron citrate or sodium citrate to the media. In the cultures supplemented with iron, we found that cell-associated iron increased rapidly while culture densities were not significantly different over 4 hours when...
ORGANISM(S): Pseudomonas syringae pv. tomato str. DC3000 
2008-11-07 | E-GEOD-13500 | biostudies-arrayexpress
UnknownInterleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.
Not available
S-EPMC6935243 | biostudies-literature
TranscriptomicsTranscription profiling of human peripheral blood from relapsing-remitting MS patients either untreated or treated with glatiramer acetate or interferon beta
One of our new major finding among the genes that contributes to MS susceptibility is ICSBP1. The so called disease modifying therapies like interferon-beta (IFN-β), possibly acting on the peripheral T-cells, reduce the disease activity and the clinical progression, with a MRI-detectable effect in ...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-16214 | biostudies-arrayexpress
TranscriptomicsIdentification of Sox9-Regulated Pathways During the Secondary Transition Stage of Pancreas Development
Sox9 target genes were identified during the secondary transition stage of pancreas development by comparing gene expression in Sox9-ablated versus wild-type pancreata using microarray analysis. Sox9 was conditionally ablated during the secondary transition in the developing pancreas via recombinati...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-28670 | biostudies-arrayexpress
UnknownAn Evolutionary Comparison of the Handicap Principle and Hybrid Equilibrium Theories of Signaling.
Not available
S-EPMC4562630 | biostudies-literature
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