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TranscriptomicsPHK Cells: control vs. cyclosporine vs. 11R-VIVIT
Calcineurin/NFAT signaling pathway has been shown to play important roles in various tissues such as the immune system, cardiac muscle and neuron. Although recent studies have shown that the pathway is involved in the regulation of hair growth, the precise mechanism is still unclear. In this study, ...
ORGANISM(S): Homo sapiens 
2010-11-08 | E-GEOD-25175 | biostudies-arrayexpress
ProteomicsConfirmation of the phosphorylation sites of human PhK
The activity of PhK is regulated by phosphorylation, and we utilized single-particle cryo-electron microscopy to solve the high-resolution structures of human PhK under phosphorylation and calcium ion activation. To gain a deeper insight into the phosphorylation sites following PKA treatment, we emp...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059345 | Pride
Phosphorylation sites，phk 
ProteomicsCross-Link of inactive PhK and GP
Phosphorylase kinase (PhK) phosphorylates GP to initiate glycogenolysis. To gain insights into the mechanism of PhK catalyzing GP phosphorylation, we have tried a variety of methods to obtain the hPhK-GP complex, but none of them were successful. Eventually, we decided to employ XL-MS to investigate...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059356 | Pride
Phk Gp Xl-ms 
ProteomicsCross-Link of active PhK and GP
Phosphorylase kinase (PhK) phosphorylates GP to initiate glycogenolysis. To gain insights into the mechanism of PhK catalyzing GP phosphorylation, we have tried a variety of methods to obtain the hPhK-GP complex, but none of them were successful. Eventually, we decided to employ XL-MS to investigate...
ORGANISM(S): Hordeum vulgare (Barley) 
2025-05-07 | PXD059369 | Pride
Phk Active state Gp Xl-ms 
TranscriptomicsPHK Cells: control vs. cyclosporine vs. 11R-VIVIT
Calcineurin/NFAT signaling pathway has been shown to play important roles in various tissues such as the immune system, cardiac muscle and neuron. Although recent studies have shown that the pathway is involved in the regulation of hair growth, the precise mechanism is still unclear. In this study, ...
ORGANISM(S): Homo sapiens 
2010-11-08 | GSE25175 | GEO
TranscriptomicsGene expression profiling of cidofovir treatment and resistance inHeLa, HaCaT, and PHK cells
Cidofovir is an acyclic nucleoside phosphonate with strong antiviral activity against a broad spectrum of DNA viruses. Although it has previously been shown that cidofovir exerts an antiproliferative effect on HPV positive cells by the induction of apoptosis, the exact mechanism of action remains to...
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-39293 | biostudies-arrayexpress
GenomicsHomo sapiens
PHK Cells: control vs. cyclosporine vs. 11R-VIVIT
PRJNA134435 | ENA
TranscriptomicsGene expression profiling of cidofovir treatment and resistance inHeLa, HaCaT, and PHK cells
Cidofovir is an acyclic nucleoside phosphonate with strong antiviral activity against a broad spectrum of DNA viruses. Although it has previously been shown that cidofovir exerts an antiproliferative effect on HPV positive cells by the induction of apoptosis, the exact mechanism of action remains to...
ORGANISM(S): Homo sapiens 
2013-07-03 | GSE39293 | GEO
GenomicsHomo sapiens
Gene expression profiling of cidofovir treatment and resistance inHeLa, HaCaT, and PHK cells
PRJNA170506 | ENA
TranscriptomicsStudies on the production of fungal polyketides in Aspergillus nidulans using systems biology tools
Using genetic engineering tools available for the model organism Aspergillus nidulans, we constructed two recombinant strains; one expressing the model polyketide Penicillium griseofulvum 6-methylsalicylic acid (6-MSA) polyketide synthase gene, and one expressing the 6-MSA gene and overexpressing th...
ORGANISM(S): Emericella nidulans 
2009-02-27 | E-GEOD-12859 | biostudies-arrayexpress
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