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ProteomicsFunctional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma
CD38 is a surface ectoenzyme expressed at high levels on myeloma plasma cells and is the target for the monoclonal antibodies (mAbs) daratumumab and isatuximab. CD38 density on tumor cells is an important determinant of mAb efficacy while CD38 is lost after mAb treatment. Several small molecules hav...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD027594 | Pride
Crispr-interference Atra Myeloma surfaceome Azacytidine Cd38 Panobinostat Daratumamab Phosphoproteomics 
ProteomicsProteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
Resistance to proteasome inhibitors (PIs) is a ubiquitous clinical concern in multiple myeloma. We proposed that signaling-level responses after PI would reveal new means to enhance efficacy. Unbiased phosphoproteomics after the PI carfilzomib surprisingly demonstrated the most prominent phosphory...
ORGANISM(S): Homo sapiens (Human) 
2020-02-21 | PXD012172 | Pride
Cancer Multiple myeloma Splice factor Spliceosome Lc-msms phosphoproteomics Proteasome inhibition Splicing Alternative splicing 
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