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ProteomicsPhospho-tyrosine proteomic analysis in Ptprd-meB+/– mice
PTPδ, encoded by PTPRD, is implicated in various neurological, psychiatric, and neurodevelopmental disorders, but the underlying mechanisms remain unclear. PTPδ trans-synaptically interacts with multiple postsynaptic adhesion molecules, which involves its extracellular alternatively spliced mini-exo...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-01 | PXD053554 | Pride
Phospho-tyrosine proteomic analysis Ptprd-meb Lc-ms/ms 
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
TranscriptomicsA spatial vascular transcriptomic, proteomic and phosphoproteomic atlas unveils an angiocrine Tie Wnt signaling axis in the liver
Single cell transcriptomic analyses (scRNAseq) of hepatocytes and liver endothelial cells (L-EC) have revolutionized the understanding of the spatial architecture of liver structure and function. The spatial alignment of L-EC and hepatocytes is pivotal for liver function in health and disease given ...
ORGANISM(S): Mus musculus 
2021-05-20 | GSE155797 | GEO
ProteomicsTemporal (phospho-)proteomic profiling of neurotrophic receptor tyrosine kinase signalling in neuroblastoma cells
Neurotrophic receptor tyrosine kinases, also known as Tropomyosin receptor kinases (TrkA, TrkB and TrkC), despite their homology, contribute to the clinical heterogeneity of childhood cancer neuroblastoma. TrkA expression is associated with low-stage disease and is often seen with spontaneous tumour...
ORGANISM(S): Homo sapiens (Human) 
2024-08-29 | PXD054441 | Pride
Neuroblastoma Trk Phosphoproteome Proteome 
GenomicsA spatial vascular transcriptomic, proteomic and phosphoproteomic atlas unveils an angiocrine Tie Wnt signaling axis in the liver
A spatial vascular transcriptomic, proteomic and phosphoproteomic atlas unveils an angiocrine Tie Wnt signaling axis in the liver
PRJNA655674 | ENA
ProteomicsRegulation of stress signaling by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are ...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-24 | PXD031890 | Pride
Phospholipid Stress signaling Monounsaturated fatty acid Lc-mse Mouse fibroblasts 
ProteomicsLC-MSMS based (phospho)proteomics on gastric cancer cell lines
We exploit a large panel of gastric cancer cell lines and three powerful (phospho)proteomic workflows, including tyrosine phosphorylation profiling, to provide the characterization of the gastric cancer proteome. The resulting datasets are used individually and in an integrated manner to generate no...
ORGANISM(S): Homo sapiens (Human) 
2024-12-16 | PXD048538 | Pride
Lc-msms Proteomics Gastric cancer Tyrosine phosphorylation profiling Phosphoproteomics 
UnknownPhospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling.
Not available
S-EPMC3063577 | biostudies-literature
UnknownSpatial proteomic and phospho-proteomic organization in three prototypical cell migration modes.
Not available
S-EPMC4077045 | biostudies-literature
ProteomicsUnbiased proteomic and phosphoproteomic analysis identifies response signatures and novel susceptibilities after combined MEK and mTOR inhibition in BRAFV600E mutant glioma
The mitogen-activated protein kinase (MAPK) pathway is one of the most altered pathways in cancer. It is involved in the control of cell proliferation, invasion, metabolism, and resistance to therapy. A number of aggressive malignancies, including melanoma, colon cancer and glioma, are driven by an ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-07-30 | PXD022329 | Pride
Glioma  braf v600e  trametinib  tak228  sapanisertib  ink128  mln0128 
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